Exposure Assessment and Risk Characterization for Perfluorooctanoate in Selected Consumer Articles
详细信息 查看全文
- 作者：Stephen T. Washburn ; Timothy S. Bingman ; Scott K. Braithwaite ; Robert C. Buck ; L. William Buxton ; Harvey J. Clewell ; Lynne A. Haroun ; Janet E. Kester ; Robert W. Rickard ; and Annette M. Shipp
- 刊名：Environmental Science & Technology
- 出版年：2005
- 出版时间：June 1, 2005
- 年：2005
- 卷：39
- 期：11
- 页码：3904 - 3910
- 全文大小：96K
- 年卷期：v.39,no.11(June 1, 2005)
- ISSN：1520-5851
文摘
An exposure assessment and risk characterization wasconducted to better understand the potential human healthsignificance of trace levels of perfluorooctanoate (PFO)detected in certain consumer articles. PFO is the anion ofperfluorooctanoic acid (PFOA). Concentrations of PFO inthe consumer articles were determined from extraction testsand product formulation information. Potential exposuresduring consumer use of the articles were quantified basedon an assessment of behavior patterns and regulatoryguidance. Health benchmarks were developed and thencompared to the exposure estimates to yield margins ofexposure (MOEs). A simple one-compartment model wasalso developed to estimate contributions of potential consumerexposures to PFO concentrations in serum. While thereare considerable uncertainties in this assessment, it indicatesthat exposures to PFO during consumer use of thearticles evaluated in this study are not expected to causeadverse human health effects in infants, children,adolescents, adult residents, or professionals nor result inquantifiable levels of PFO in human serum.