Liquid Scintillation Counting Methodology for 99Tc Analysis: A Remedy for Radiopharmaceutical Waste

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• 作者：Mumtaz Khan ; Wooyong Um
• 刊名：Analytical Chemistry
• 出版年：2015
• 出版时间：September 1, 2015
• 年：2015
• 卷：87
• 期：17
• 页码：9054-9060
• 全文大小：332K
• ISSN：1520-6882

文摘

This paper presents a new approach for liquid scintillation counting (LSC) analysis of single-radionuclide samples containing appreciable organic or inorganic quench. This work offers better analytical results than existing LSC methods for technetium-99 (^99gTc) analysis with significant savings in analysis cost and time. The method was developed to quantify ^99gTc in environmental liquid and urine samples using LSC. Method efficiency was measured in the presence of 1.9 to 11鈥?00 ppm total dissolved solids. The resultant quench curve proved to be effective for quantifying spiked ^99gTc activity in deionized water, tap water, groundwater, seawater, and urine samples. Counting efficiency was found to be 91.66% for Ultima Gold LLT (ULG-LLT) and Ultima Gold (ULG). Relative error in spiked ^99gTc samples was 卤3.98% in ULG and ULG-LLT cocktails. Minimum detectable activity was determined to be 25.3 and 22.7 mBq for ULG-LLT and ULG cocktails, respectively. A preconcentration factor of 1000 was achieved at 100 掳C for 100% chemical recovery.