Spontaneous Vesicle Formation of Poly(ethylene oxide)−Poly(propylene oxide)−Poly(ethylene oxide) Triblock Copolymer

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• 作者：Shu Chen ; Bin Yang ; Chen Guo ; Jun-He Ma ; Liang-Rong Yang ; Xiangfeng Liang ; Chao Hua ; Hui-Zhou Liu
• 刊名：Journal of Physical Chemistry B
• 出版年：2008
• 出版时间：December 11, 2008
• 年：2008
• 卷：112
• 期：49
• 页码：15659-15665
• 全文大小：252K
• 年卷期：v.112,no.49(December 11, 2008)
• ISSN：1520-5207

文摘

A novel method has been developed to prepare vesicles from aqueous solutions of poly(ethylene oxide)−poly(propylene oxide)−poly(ethylene oxide) triblock copolymer, by adding anionic surfactant sodium dodecyl sulfate (SDS) and inorganic salt NaF. As determined by TEM and dynamic light scattering (DLS) measurements, the average diameter of vesicles is about 800 nm having 50 nm outer shell thickness. Identifying hydrophobic interactions between the block copolymers and the microenvironments around the vesicles using FTIR, ¹H NMR, and fluorescence spectroscopy techniques revealed the vesicle formation mechanism. The spontaneously formed vesicles were further cross-linked by converting the terminal hydroxyl groups of block copolymers into aldehydes, and then chemically bridging the polymer chains by the reaction between aldehydes and diamine compounds. The cross-linked vesicles are proved much more stable than free vesicles even at higher dilutions. The obtained vesicles with good stability and biocompatibility are promising candidates for widespread applications.