Kinetic Resolution of Hindered Morita鈥揃aylis鈥揌illman Adducts by Rh(I)-Catalyzed Asymmetric 1,4-Addition/尾-Hydroxyelimination

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• 作者：Yazhou Wang ; Xiangqing Feng ; Haifeng Du
• 刊名：Organic Letters
• 出版年：2011
• 出版时间：September 16, 2011
• 年：2011
• 卷：13
• 期：18
• 页码：4954-4957
• 全文大小：791K
• 年卷期：v.13,no.18(September 16, 2011)
• ISSN：1523-7052

文摘

A kinetic resolution of hindered Morita鈥揃aylis鈥揌illman adducts has been successfully achieved in excellent selectivities via Rh(I)-catalyzed asymmetric 1,4-addition/尾-hydroxyelimination with the use of a chiral sulfinamide/olefin hybrid ligand. This study provides a novel and efficient access to both optically active hindered highly functionalized alkenes and Morita鈥揃aylis鈥揌illman adducts.