Discovery of Multitarget Inhibitors by Combining Molecular Docking with Common Pharmacophore Matching

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• 作者：Dengguo Wei ; Xiaolu Jiang ; Lu Zhou ; Jing Chen ; Zheng Chen ; Chong He ; Kun Yang ; Ying Liu ; Jianfeng Pei ; Luhua Lai
• 刊名：Journal of Medicinal Chemistry
• 出版年：2008
• 出版时间：December 25, 2008
• 年：2008
• 卷：51
• 期：24
• 页码：7882-7888
• 全文大小：221K
• 年卷期：v.51,no.24(December 25, 2008)
• ISSN：1520-4804

文摘

Multitarget drugs have been to be found effective in controlling complex diseases. However, how to design multitarget drugs presents a great challenge. We have developed a computer-assisted strategy to screen for multitarget inhibitors using a combination of molecular docking and common pharmacophore matching. This strategy was successfully applied to screen for dual-target inhibitors against both the human leukotriene A₄ hydrolase (LTA4H-h) and the human nonpancreatic secretory phospholipase A2 (hnps-PLA2). Three compounds screened from the chemical database MDL Available Chemical Directory were found to inhibit these two enzymes at the 10 μM level. Moreover, one synthetic compound matching the common pharmacophores inhibits LTA4H-h and hnps-PLA2 with IC₅₀ values of 35 nM and 7.3 μM, respectively. The common pharmacophore model can also be used to search small molecule databases or collections of existing inhibitors, as well as to guide combinatorial library design to search for ideal multitarget inhibitors.