Evolution of Pyrrolidine-Type Asymmetric Organocatalysts by "Click" Chemistry

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• 作者：Sanzhong Luo ; Hui Xu ; Xueling Mi ; Jiuyuan Li ; Xiaoxi Zheng ; Jin-Pei Cheng
• 刊名：Journal of Organic Chemistry
• 出版年：2006
• 出版时间：November 24, 2006
• 年：2006
• 卷：71
• 期：24
• 页码：9244 - 9247
• 全文大小：117K
• 年卷期：v.71,no.24(November 24, 2006)
• ISSN：1520-6904

文摘

Click chemistry has been employed to construct a library ofthe pyrrolidine-type asymmetric organocatalysts. The clickedorganocatalysts were evaluated in asymmetric Michaeladdition of ketones to nitroolefins, showing good catalyticactivity and stereoselectivity (up to 100% yield, syn:anti =99:1, 96% ee).