Polysubstituted 2-Aminopyrrole Synthesis via Gold-Catalyzed Intermolecular Nitrene Transfer from Vinyl Azide to Ynamide: Reaction Scope and Mechanistic Insights
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- 作者：Yufeng Wu ; Lei Zhu ; Yinghua Yu ; Xuesong Luo ; Xueliang Huang
- 刊名：Journal of Organic Chemistry
- 出版年：2015
- 出版时间：November 20, 2015
- 年：2015
- 卷：80
- 期：22
- 页码：11407-11416
- 全文大小：657K
- ISSN：1520-6904
文摘
A gold-catalyzed intermolecular reaction of vinyl azides and ynamides is described. This process presents an efficient and mild approach to multisubstituted 2-aminopyrroles in good-to-excellent yields. Control experiments were carried out to distinguish the reactivity between vinyl azides and the corresponding 2H-azirines. A plausible reaction mechanism was also proposed according to previous reports and our preliminary mechanistic studies.