CuSO4-Mediated Decarboxylative Difluoroacetamidation of α,β-Unsaturated Carboxylic Acids
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- 作者：Qiao Chen ; Chao Wang ; Jiawei Zhou ; Yanan Wang ; Zhaoqing Xu ; Rui Wang
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：March 18, 2016
- 年：2016
- 卷：81
- 期：6
- 页码：2639-2645
- 全文大小：438K
- ISSN：1520-6904
文摘
The first example of decarboxylative difluoroacetamidation of α,β-unsaturated carboxylic acids by using difluoromethyl-substituted carbonyl compounds was disclosed. The procedure, which was mediated by low-cost and benign CuSO4, furnished a broad range of difluorinated alkenes in remarkable yields with only the E configuration in most of the cases. Moreover, the product could be smoothly transformed to the corresponding difluorofunctionalized ester and alcohol in high yields.