N-Heterocyclic Carbene-Catalyzed Chemoselective Cross-Aza-Benzoin Reaction of Enals with Isatin-Derived Ketimines: Access to Chiral Quaternary Aminooxindoles

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• 作者：Jianfeng Xu ; Chengli Mou ; Tingshun Zhu ; Bao-An Song ; Yonggui Robin Chi
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：June 20, 2014
• 年：2014
• 卷：16
• 期：12
• 页码：3272-3275
• 全文大小：323K
• 年卷期：v.16,no.12(June 20, 2014)
• ISSN：1523-7052

文摘

A chemo- and enantioselective cross-aza-benzoin reaction between enals and isatin-derived ketimines is disclosed. The high chemoselectivity (of the acyl anion reaction over enal 伪- and 尾-carbon reactions) is enabled by the electronic and steric properties of the N-heterocyclic carbene organocatalyst.