Construction of 9H-Pyrrolo[1,2-a]indoles by a Copper-Catalyzed Friedel–Crafts Alkylation/Annulation Cascade Reaction
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- 作者：Yongqing Sun ; Yu Qiao ; Haiying Zhao ; Baoguo Li ; Shufeng Chen
- 刊名：Journal of Organic Chemistry
- 出版年：2016
- 出版时间：December 2, 2016
- 年：2016
- 卷：81
- 期：23
- 页码：11987-11993
- 全文大小：407K
- ISSN：1520-6904
文摘
An efficient and concise Cu(OTf)2-catalyzed Friedel–Crafts alkylation/annulation cascade reaction of substituted indoles with 1,2-dicarbonyl-3-enes has been established. This reaction uses readily available starting materials and is operationally simple, thus representing a practical method for the construction of diverse 9H-pyrrolo[1,2-a]indoles bearing a carbonyl group.