Visible-Light-Induced Direct Difluoroalkylation of Uracils, Pyridinones, and Coumarins

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• 作者：Chun-Yang HeJingjing Kong ; Xuefei Li ; Xiaofei Li ; Qiuli Yao ; Fu-Ming Yuan
• 刊名：Journal of Organic Chemistry
• 出版年：2017
• 出版时间：January 20, 2017
• 年：2017
• 卷：82
• 期：2
• 页码：910-917
• 全文大小：441K
• ISSN：1520-6904

文摘

An efficient and general method for the synthesis of difluoroalkylated uracils, pyridinones, and coumarins through visible-light-induced reaction with commercial materials is developed. The strategy proceeds with high efficiency under mild reaction conditions and shows excellent functional group compatibility, even toward bromide and hydroxyl group, thus demonstrates high potent application in a late-stage fluoroalkylation. Moreover, the difluoroalkylated products can be further transformed to a diverse variety of difluoroalkylated heterocycles, including molecules of potential biological activity.