Isocyanide Insertion: De Novo Synthesis of Trifluoromethylated Phenanthridine Derivatives

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• 作者：Yuanzheng Cheng ; Heng Jiang ; Yan Zhang ; Shouyun Yu
• 刊名：Organic Letters
• 出版年：2013
• 出版时间：November 1, 2013
• 年：2013
• 卷：15
• 期：21
• 页码：5520-5523
• 全文大小：275K
• 年卷期：v.15,no.21(November 1, 2013)
• ISSN：1523-7052

文摘

A mechanistically new strategy has been described for the simple, practical, and environmentally friendly preparation of 6-(trifluoromethyl)phenanthridine derivatives using ionic isocyanide insertion from biphenyl isocyanide derivatives and Umemoto鈥檚 reagent. These reactions were promoted only by inorganic base in good-to-excellent chemical yields without any external stoichiometric oxidants and radical initiators.