Direct Oxidative Coupling of Enamines and Electron-Deficient Amines: TBAI/TBHP-Mediated Synthesis of Substituted Diaminoalkenes under Metal-Free Conditions
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- 作者：Yucheng Yuan ; Wenjuan Hou ; Daisy Zhang-Negrerie ; Kang Zhao ; Yunfei Du
- 刊名：Organic Letters
- 出版年：2014
- 出版时间：October 17, 2014
- 年：2014
- 卷：16
- 期：20
- 页码：5410-5413
- 全文大小：392K
- ISSN：1523-7052
文摘
A metal-free cross-coupling of enamines and electron-deficient amines through oxidative C(sp2)鈥揘 bond formation has been realized by using TBAI as catalyst and TBHP as oxidant. This novel strategy allows for an efficient organocatalytic synthesis of the synthetically useful diaminoalkene derivatives and is highlighted by appealing features such as readily available of the starting materials, wide substrate scope and transition-metal-free characteristics.