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Formation of N-Alkoxyindole Framework: Intramolecular Heterocyclization of 3-Alkoxyimino-2-arylalkylnitriles Mediated by Ferric Chloride
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  • 作者:Yunfei Du ; Junbiao Chang ; John Reiner ; Kang Zhao
  • 刊名:Journal of Organic Chemistry
  • 出版年:2008
  • 出版时间:March 7, 2008
  • 年:2008
  • 卷:73
  • 期:5
  • 页码:2007 - 2010
  • 全文大小:144K
  • 年卷期:v.73,no.5(March 7, 2008)
  • ISSN:1520-6904
文摘
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A variety of functionalized N-alkoxyindole-3-carbonitrilederivatives are achieved under remarkably mild conditionsby applying a FeCl3-mediated intramolecular heterocyclization of 3-alkoxyimino-2-arylalkylnitriles. This novel synthesisallows the N-moiety on the side chain to be annulated to thebenzene ring as the final synthetic step, which enables thefunctionalization of the benzenoid portion of the indole atan early stage of the synthesis.

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