Radical ipso-Substitution of a Carbon鈥揊luorine Bond Leading to Fluoro-7-azaindolines and Fluoro-7-azaindoles

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• 作者：Zhibo Liu ; Ling Qin ; Samir Z. Zard
• 刊名：Organic Letters
• 出版年：2014
• 出版时间：May 16, 2014
• 年：2014
• 卷：16
• 期：10
• 页码：2704-2707
• 全文大小：426K
• 年卷期：v.16,no.10(May 16, 2014)
• ISSN：1523-7052

文摘

Rare examples of a synthetically useful radical ipso-substitution of a carbon鈥揻luorine bond are reported, leading to highly functionalized 5,6-difluoro-7-azaindolines. An unexpected hydrogen atom translocation and fragmentation with loss of molecular nitrogen and formation of a nitrile were observed in the case of an N-benzyl-tetrazole derivative.