Nitric Oxide Inhibitory Meroterpenoids from the Fungus Penicillium purpurogenum MHZ 111

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• 作者：Jing Sun ; Zhi-Xiang Zhu ; Yue-Lin Song ; Dan Dong ; Jiao Zheng ; Ting Liu ; Yun-Fang Zhao ; Daneel Ferreira ; Jordan K. Zjawiony ; Peng-Fei Tu ; Jun Li
• 刊名：Journal of Natural Products
• 出版年：2016
• 出版时间：May 27, 2016
• 年：2016
• 卷：79
• 期：5
• 页码：1415-1422
• 全文大小：504K
• 年卷期：0
• ISSN：1520-6025

文摘

Five new meroterpenoids, purpurogenolides A–E (1–5), and four known metabolites (6–9) were isolated from the solid substrate fermentation cultures of the fungus Penicillium purpurogenum MHz 111. The structures of the new meroterpenoids were elucidated by analysis of spectroscopic and spectrometric data (1D and 2D NMR, IR, and HRESIMS). The absolute configurations of 1 and 5 were determined by single-crystal X-ray crystallographic analysis, and those of 2–4 were elucidated on the basis of experimental and calculated electronic circular dichroism spectra. Compounds 2–4 and 6 showed inhibition of nitric oxide production in lipopolysaccharide-activated BV-2 microglial cells with IC₅₀ values of 0.8–30.0 μM.