Membrane Fusion-Mediated Gold Nanoplating of Red Blood Cell: A Bioengineered CT-Contrast Agent

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• 作者：Santosh AryalTuyen Duong Thanh Nguyen ; Arunkumar Pitchaimani ; Tej B. Shrestha ; David Biller ; Deryl Troyer
• 刊名：ACS Biomaterials Science & Engineering
• 出版年：2017
• 出版时间：January 9, 2017
• 年：2017
• 卷：3
• 期：1
• 页码：36-41
• 全文大小：464K
• ISSN：2373-9878

文摘

Red blood cells (RBCs) are the natural resident of the vascular lumen, therefore delivery of any agents within the vascular lumen could benefit by unique natural transporting features of RBCs. RBCs continuously circulate for ∼100 days before being sequestered in the spleen, they only extravasate at sites of vascular hemorrhage. Taking advantages of these features, we engineered RBC as a carrier in order to design a unique delivery system capable of delivering X-ray computed tomography (CT) contrast agents, gold nanoparticles (AuNPs), thereby acting as CT-contrast agent. A strategic membrane fusion technique was used to engineer the surface of RBC with gold nanoparticles in this in vitro study without altering its shape, size, and surface properties.