Sulfoxide-Directed Enantioselective Synthesis of Functionalized Tetrahydropyridines
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- 作者：Roberto Fern谩ndez de la Pradilla ; Carmen Simal ; Robert H. Bates ; Alma Viso ; Lourdes Infantes
- 刊名：Organic Letters
- 出版年：2013
- 出版时间：October 4, 2013
- 年：2013
- 卷：15
- 期：19
- 页码：4936-4939
- 全文大小：255K
- 年卷期：v.15,no.19(October 4, 2013)
- ISSN：1523-7052
文摘
The highly selective base-promoted cyclization of enantiopure sulfinyl dienamines provides stereodefined sulfinyl 1,2,3,6-tetrahydropyridines (dr up to 99:1). Subsequent sigmatropic rearrangement affords tetrahydropyridin-3-ols in good yields and selectivities.