Isolation, identification, and cytotoxicity of a new isobenzofuran derivative from marine Streptomyces sp. W007

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• 作者：Hongyu Zhang 张宏嬿/a> ; Zeping Xie 谢则巿/a>…
• 关键词：marine streptomycete ; isobenzofuran derivative ; absolute configuration ; cytotoxicity
• 刊名：Chinese Journal of Oceanology and Limnology
• 出版年：2016
• 出版时间：March 2016
• 年：2016
• 卷：34
• 期：2
• 页码：386-390
• 全文大小：231 KB
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• 作者单位：Hongyu Zhang 张宏宇 (1)
  Zeping Xie 谢则平 (3)
  Tingting Lou 娄婷婷 (4)
  Peng Jiang 姜鹏 (2)
  
  1. Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science, Tianjin University of Commerce, Tianjin, 300134, China
  3. School of Pharmacy, Binzhou Medical University, Yantai, 264003, China
  4. Tianjin Entry & Exit Inspection and Quarantine Bureau, Tianjin, 300461, China
  2. Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, 266071, China
  
• 刊物主题：Oceanography;
• 出版者：Springer Berlin Heidelberg
• ISSN：1993-5005

文摘

A new isobenzofuran derivative (1) was isolated from the marine Streptomyces sp. W007 and its structure was determined through extensive spectroscopic analyses, including 1D-NMR, 2D-NMR, and ESI-MS. The absolute configuration of compound 1 was determined by a combination of experimental analyses and comparison with reported data, including biogenetic reasoning, J-coupling analysis, NOESY, and 1H-1HCOSY. Compound 1 exhibited no cytotoxicity against human cells of gastric cancer BGC-823, lung cancer A549, and breast cancer MCF7.