The Association Between Systemic Sclerosis, Arginine and Asymmetric Dimethylarginine

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• 作者：Li Zhang (1)
  Ya-Nan Wan (2)
  Jiu-Hua Zhao (3)
  Yu-Jie Wang (2)
  Ying-xin Wang (1)
  Jun-Wei Yan (2)
  Xiao-Lei Huang (2)
  Jing Wang (2)
  
  1. Medical Genetics Center ; Anhui Medical College ; Hefei ; China
  2. Department of Epidemiology and Biostatistics ; School of Public Health ; Anhui Medical University ; No. 81 ; Meishan Road ; Hefei ; Anhui ; 230032 ; People鈥檚 Republic of China
  3. West Anhui Health Vocational College ; Lu鈥檃n ; China
  
• 关键词：asymmetric dimethylarginine ; systemic sclerosis ; nitric oxide ; arginine
• 刊名：Inflammation
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：38
• 期：1
• 页码：218-223
• 全文大小：199 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Rheumatology
  Internal Medicine
  Pharmacology and Toxicology
  Pathology
  
• 出版者：Springer Netherlands
• ISSN：1573-2576

文摘

Systemic sclerosis (SSc) is a kind of autoimmune disease characterized by inflammatory and endothelial dysfunction. Asymmetric dimethylarginine (ADMA), as an endogenous nitric oxide synthase inhibitor, can cause or contribute to the inflammatory syndrome and endothelial dysfunction. Recently, increased ADMA levels have been demonstrated in SSc, revealing that ADMA might play an important role for the associated manifestations of SSc. Besides, ADMA may play a significant role in the level of NO, which is produced by arginine. In the review, we discuss the role of arginine and ADMA in patients with SSc.