Clinical efficacy of 9-oxo-10, 11-dehydroageraphorone extracted from Eupatorium adenophorum against Psoroptes cuniculi in rabbits
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- 作者：Yang Hu (1)
Fei Liao (1) (2)
Yanchun Hu (1)
Biao Luo (1)
Yajun He (1)
Quan Mo (1)
Zhicai Zuo (1)
Zhihua Ren (1)
Junliang Deng (1)
Yahui Wei (3)
1. Key laboratory of Animal Disease and Human Health of Sichuan Province ; College of Veterinary ; Medicine ; Sichuan Agricultural University ; Sichuan Province ; Ya an ; 625014 ; China
2. Qiandongnan Prefectural Center for Animal Disease Control and Prevention of Guizhou province ; Kaili ; 556000 ; China
3. Key Laboratory of Resource Biology and Biotechnology in Western China ; School of Life Science ; Northwest University ; Xi鈥檃n ; 710069 ; China - 关键词：Euptox A ; Eupatorium adenophorum ; Psoroptes cuniculi ; Acaricidal ; Clinical efficacy
- 刊名：BMC Veterinary Research
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：10
- 期：1
- 全文大小：1,305 KB
- 参考文献：1. Shang, XF, Miao, XL, Wang, DS, Li, JX, Wang, XZ, Yan, ZT, Wang, CM, Wang, Y, He, XR, Hu, P (2013) Acaricidal activity of extracts from Adonis Coerulea Maxim. Against Psoroptes Cuniculi in vitro and in vivo. Vet Parasitol 195: pp. 136-141 CrossRef
2. Borges, FA, Almeida, GD, Heckler, RP, Lemes, RT, Onizuka MK, DGB (2013) Anthelmintic resistance impact on tropical beef cattle productivity: effect on weight gain of weaned calves. Trop Anim Heal Pro 45: pp. 723-727 CrossRef
3. O鈥檚ullivan, B (1985) Investigations into crofton weed (Eupatorium adenophorum) toxicity in horses. Aust Vet J 62: pp. 30-32 CrossRef
4. Chakravarty AK, Mazumder T, Chatterjee SN: Anti-inflammatory potential of ethanolic leaf extract of Eupatorium adenophorum Spreng. Through Alteration in Production of TNF-伪, ROS and expression of certain genes. / Evid Based Complement Alternat Med 2011, doi:10.1093/ecam/neq033.
5. Nong X, Ren YJ, Wang JH, Xie Y, Fang CL, Yang DY: Clinical efficacy of botanical extracts from Eupatorium adenophorum against the Sarcoptes scabiei ( Sarcoptidae: Sarcoptes ) in Rabbits. / Vet Parasitol 2013: doi.org/10.1016/j.vetpar.2013.1002.1020.
6. Seddiek, SA, Khater, HF, El-Shorbagy, MM, Ali, AM (2013) The acaricidal efficacy of aqueous neem extract and ivermectin against Sarcoptes scabiei var. cuniculi in experimentally infested rabbits. Parasitol Res 112: pp. 2319-2330 CrossRef
7. Kundu, A, Saha, S, Walia, S, Ahluwalia, V, Kaur, C (2013) Antioxidant potential of essential oil and cadinene sesquiterpenes of Eupatorium adenophorum. Toxicol Environ Chem 95: pp. 127-137 CrossRef
8. Zou, F, Duan, G, Xie, Y, Zhou, Y, Dong, G, Lin, R, Zhu, X (2009) Molluscicidal activity of the plant Eupatorium adenophorum against Oncomelania hupensis, the intermediate host snail of Schistosoma japonicum. Ann Trop Med Parasitol 103: pp. 549-553 CrossRef
9. Romero-Cerecero, O, Zamilpa, A, Jim茅nez-Ferrer, E, Tortoriello, J (2012) Therapeutic effectiveness of Ageratina pichinchensis on the treatment of chronic interdigital Tinea Pedis: a randomized, double-blind clinical trial. J Alternative Compl Med 18: pp. 607-611 CrossRef
10. Sun, XY, Lu, ZH, Sang, WG (2004) Review on studies of Eupatorium adenophoruman important invasive species in China. J Forest Res 15: pp. 319-322 CrossRef
11. Xu, R, Wu, D, Zhang, W, Yin, F, Kuang, R (2009) Efficacy of Ageratina adenophora extract and biogas fermentation residue against the cabbage aphid, Brevicoryne brassicae and an assessment of the risk to the Parasitoid diaeretiella rapae. Int J Pest Manag 55: pp. 151-156 CrossRef
12. Seawright, A, Oelrichs, P, Ng, J, Nolan, C, Jukes, R, Davis, A (1998) GSH-dependent biliary tract toxicity in the mouse caused by 9-oxo-10, 11-dehydroageraphorone (euptox). Toxicol Lett 95: pp. 162-162 CrossRef
13. He, L, Hou, J, Gan, M, Shi, J, Chantrapromma, S, Fun, H-K, Williams, ID, Sung, HH-Y (2008) Cadinane sesquiterpenes from the leaves of Eupatorium adenophorum. J Nat Prod 71: pp. 1485-1488 CrossRef
14. Bohlmann, F, Gupta, RK (1981) Six cadinene derivatives from Ageratina adenophora. Phytochemistry 20: pp. 1432-1433 CrossRef
15. Kaushal, V, Dawra, R, Sharma, O, Kurade, N (2001) Biochemical alterations in the blood plasma of rats associated with hepatotoxicity induced by Eupatorium adenophorum. Vet Res Commun 25: pp. 601-608 CrossRef
16. Oelrichs, PB, Calanasan, CA, Macleod, JK, Seawright, AA, Ng, JC (1995) Isolation of a compound from Eupatorium adenophorum (Spreng.) [Ageratina adenophora (Spreng.)] causing hepatotoxicity in mice. Nat Toxins 3: pp. 350-354 CrossRef
17. Bai, J, Cao, A, Guo, M, Liu, X, Liu, X, Liang, H, Zhou, B (2011) Identification of 9-oxo-10,11-dehydroagerophorone in Eupatorium adenophorum by high performance liquid chromatography. Chin Bull Bot 46: pp. 470-475 CrossRef
18. Bhardwaj, R, Singh, A, Sharma, OP, Dawra, RK, Kurade, NP, Mahato, SB (2001) Hepatotoxicity and cholestasis in rats induced by the sesquiterpene, 9-oxo-10,11-dehydroageraphorone, isolated from Eupatorium adenophorum. J Biochem Mol Toxicol 15: pp. 279-286 CrossRef
19. Katoch, R, Sharma, OP, Dawra, RK, Kurade, NP (2000) Hepatotoxicity of Eupatorium adenophorum to rats. Toxicon 38: pp. 309-314 CrossRef
20. Kikuchi, T, Watanabe, K, Tochigi, Y, Yamamoto, A, Fukatsu, M, Ezaki, Y, Tanaka, R, Akihisa, T (2012) Melanogenesis inhibitory activity of sesquiterpenes from Canarium ovatum Resin in mouse B16 melanoma cells. Chem Biodivers 9: pp. 1500-1507 CrossRef
21. Sv, A, Langenfeld, A, Blond, A, Dupont, J, Nay, B, Prado, S (2012) Guaiane sesquiterpenes from Biscogniauxia nummularia featuring potent antigerminative activity. J Nat Prod 75: pp. 798-801 CrossRef
22. Trzoss, L, Xu, J, Lacoske, MH, Mobley, WC, Theodorakis, EA (2013) Illicium sesquiterpenes: divergent synthetic strategy and neurotrophic activity studies. Chemistry 19: pp. 6398-6408 CrossRef
23. Montenegro, I, Pino, L, Werner, E, Madrid, A, Espinoza, L, Moreno, L, Villena, J, Cuellar, M (2013) Comparative study on the Larvicidal activity of drimane sesquiterpenes and nordrimane compounds against drosophila melanogaster til-til. Molecules 18: pp. 4192-4208 CrossRef
24. Wube, AA, Bucar, F, Gibbons, S, Asres, K, Rattray, L, Croft, SL (2010) Antiprotozoal activity of drimane and coloratane sesquiterpenes towards Trypanosoma brucei rhodesiense and Plasmodium falciparum in vitro. Phytother Res 24: pp. 1468-1472 CrossRef
25. Liao, F, Hu, Y, Wu, L, Tan, H, Mo, Q, Luo, B, He, Y, Deng, J, Wei, Y (2014) the antitumor activity in vitro by 9-oxo-10, 11-dehydroageraphorone extracted from eupatorium adenophorum. Asian J Chem 26: pp. 7321-7323
26. Liao, F, Hu, Y, Tan, H, Wu, L, Wang, Y, Huang, Y, Mo, Q, Wei, Y (2014) Acaricidal activity of 9-oxo-10, 11-dehydroageraphorone extracted from Eupatorium adenophorum in vitro. Exp Parasitol 140: pp. 8-11 CrossRef
27. Liao, F, Wang, Y, Huang, Y, Mo, Q, Tan, H, Wei, Y, Hu, Y (2014) Isolation and identification of bacteria capable of degrading euptox A from Eupatorium adenophorum Spreng. Toxicon 77: pp. 87-92 CrossRef
28. Fichi, G, Flamini, G, Giovanelli, F, Otranto, D, Perrucci, S (2007) Efficacy of an essential oil of Eugenia caryophyllata against Psoroptes cuniculi. Exp Parasitol 115: pp. 168-172 CrossRef
29. Zhang, L, Koyyalamudi, SR, Jeong, SC, Reddy, N, Smith, PT, Ananthan, R, Longvah, T (2012) Antioxidant and immunomodulatory activities of polysaccharides from the roots of Sanguisorba officinalis. Int J Biol Macromol 51: pp. 1057-1062 CrossRef
30. Glantz SA: / Statistica per Discipline Biomediche. McGraw Hill; 2007
31. Nong X, Li SH, Chen FZ, Wang JH, Xie Y, Fang CL, Liu TF, He R, Gu XB, Peng XR: Isolation and identification of acaricidal compounds in Eupatorium adenophorum petroleum ether extract and determination of their acaricidal activity against Psoroptes cuniculi. / Vet Parasitol 2014: http://dx.doi.org/10.1016/j.vetpar.2014.1001.1002.
32. Nong, X, Ren, YJ, Wang, JH, Xie, Y, Fang, CL, Yang, DY (2013) Clinical efficacy of botanical extracts from Eupatorium adenophorum against the Sarcoptes scabiei (Sarcoptidae: Sarcoptes) in rabbits. Vet Parasitol 195: pp. 157-164 CrossRef
33. Deng, Y, Shi, D, Yin, Z, Guo, J, Jia, R, Xu, J, Song, X, Lv, C, Fan, Q, Liang, X (2012) Acaricidal activity of petroleum ether extract of neem (Azadirachta indica) oil and its four fractions separated by column chromatography against Sarcoptes scabiei var. cuniculi larvae in vitro. Exp Parasitol 130: pp. 475-477 CrossRef
34. Oelrichs, PB, Calanasan, CA, Macleod, JK, Seawright, AA, Ng, JC (1995) Isolation of a compound from Eupatorium adenophorum (Spreng.) [Ageratina adenophora (Spreng.)] causing hepatotoxicity in mice. Natural Toxins 3: pp. 350-354 CrossRef
35. Kaushal, V, Dawra, R, Sharma, O, Kurade, N (2001) Hepatotoxicity in rat induced by partially purified toxins from Eupatorium adenophorum (Ageratina adenophora). Toxicon 39: pp. 615-619 CrossRef - 刊物主题：Veterinary Medicine; Zoology; Transgenics;
- 出版者：BioMed Central
- ISSN：1746-6148
文摘
Background Animal acariasis is one of the important veterinary skin diseases. Chemical drugs have been widely used to treat and control this kind of disease. But many chemicals control could increase resistance in target species, toxicity and environmental hazards. We found that the 9-oxo-10, 11-dehydroageraphorone (euptox A) extracted from E. adenophorum has strong toxicity against P. cuniculi in vitro, but the in vivo acaricidal actions of euptox A have yet to be investigated. Results A 14-day experiment was performed using rabbits that were naturally infested with P. cuniculi on a farm. Rabbits were randomly divided into five groups; animals in groups A, B and C were treated in each ear topically with 4.0 ml of 2.0 and 1.0 g/L (w/v) euptox A, respectively. Animals in groups D and E were treated with ivermectin (by injection; positive controls) and glycerol with water only (by embrocation; negative controls), respectively. Each rabbit was treated twice with separate treatments on days 0 and 7. Rabbits were observed daily and detailed examinations were performed on days 0, 7 and 14, to inspect the presence or absence of mites and scabs/crusts. Seven days after the initial treatment, the mean clinical scores (presence of scabs/crusts) decreased from 3.48, 3.37, 3.43 and 3.45 to 0.37, 0.42, 0.78 and 0.38 in the ears of animals in groups A, B , C and D, respectively, which were similar to the observations recorded in the positive control rabbits. However, the clinical score for negative control rabbits did not increase significantly (P > 0.05) during the experiment, and this changed from 3.32 to 3.37 in the ears, and there were no significant differences in clinical efficacy between left and right ears. After two treatments (0 and 7 d), the rabbits in groups A, B, C and D had recovered completely 14 days after the last treatment and no recurrences of infection were observed. Conclusions These results indicate that euptox A was potent compounds for the effective control of animal P. cuniculi in vivo.