DNA damage response in cisplatin-induced nephrotoxicity
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- 作者：Shiyao Zhu ; Navjotsingh Pabla ; Chengyuan Tang ; Liyu He…
- 关键词：Cisplatin ; Nephrotoxicity ; Apoptosis ; Kidney ; DNA damage ; P53
- 刊名：Archives of Toxicology
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：89
- 期：12
- 页码：2197-2205
- 全文大小：812 KB
- 参考文献：Basu A, Krishnamurthy S (2010) Cellular responses to cisplatin-induced DNA damage. J Nucleic Acids. doi:10.鈥?061/鈥?010/鈥?01367
Bowden NA (2014) Nucleotide excision repair: why is it not used to predict response to platinum-based chemotherapy? Cancer Lett 346:163鈥?71. doi:10.鈥?016/鈥媕.鈥媍anlet.鈥?014.鈥?1.鈥?05 CrossRef PubMed
Cepeda V, Fuertes MA, Castilla J, Alonso C, Quevedo C, Perez JM (2007) Biochemical mechanisms of cisplatin cytotoxicity. Anticancer Agents Med Chem 7:3鈥?8CrossRef PubMed
Choi HJ et al (2013) NEK8 links the ATR-regulated replication stress response and S phase CDK activity to renal ciliopathies. Mol Cell 51:423鈥?39. doi:10.鈥?016/鈥媕.鈥媘olcel.鈥?013.鈥?8.鈥?06 PubMedCentral CrossRef PubMed
Ciccia A, Elledge SJ (2010) The DNA damage response: making it safe to play with knives. Mol Cell 40:179鈥?04. doi:10.鈥?016/鈥媕.鈥媘olcel.鈥?010.鈥?9.鈥?19 PubMedCentral CrossRef PubMed
Cuadrado M, Martinez-Pastor B, Murga M, Toledo LI, Gutierrez-Martinez P, Lopez E, Fernandez-Capetillo O (2006) ATM regulates ATR chromatin loading in response to DNA double-strand breaks. J Exp Med 203:297鈥?03. doi:10.鈥?084/鈥媕em.鈥?0051923 PubMedCentral CrossRef PubMed
Cummings BS, Schnellmann RG (2002) Cisplatin-induced renal cell apoptosis: caspase 3-dependent and -independent pathways. J Pharmacol Exp Ther 302:8鈥?7CrossRef PubMed
Dasari S, Tchounwou PB (2014) Cisplatin in cancer therapy: molecular mechanisms of action. Eur J Pharmacol 740:364鈥?78. doi:10.鈥?016/鈥媕.鈥媏jphar.鈥?014.鈥?7.鈥?25 CrossRef PubMed
Di C et al (2013) Mechanisms, function and clinical applications of DNp73. Cell Cycle 12:1861鈥?867. doi:10.鈥?161/鈥媍c.鈥?4967 PubMedCentral CrossRef PubMed
Francescato HD, Costa RS, Junior FB, Coimbra TM (2007) Effect of JNK inhibition on cisplatin-induced renal damage. Nephrol Dial Transplant 22:2138鈥?148. doi:10.鈥?093/鈥媙dt/鈥媑fm144 CrossRef PubMed
Fujikawa Y, Kawanishi M, Kuraoka I, Yagi T (2014) Frequencies of mutagenic translesion DNA synthesis over cisplatin-guanine intra-strand crosslinks in lacZ plasmids propagated in human cells. Mutat Res Genet Toxicol Environ Mutagen 770:23鈥?8. doi:10.鈥?016/鈥媕.鈥媘rgentox.鈥?014.鈥?5.鈥?06 CrossRef PubMed
Gonfloni S et al (2009) Inhibition of the c-Abl-TAp63 pathway protects mouse oocytes from chemotherapy-induced death. Nat Med 15:1179鈥?185. doi:10.鈥?038/鈥媙m.鈥?033 CrossRef PubMed
Guggenheim ER, Xu D, Zhang CX, Chang PV, Lippard SJ (2009) Photoaffinity isolation and identification of proteins in cancer cell extracts that bind to platinum-modified DNA. Chembiochem Eur J Chem Biol 10:141鈥?57. doi:10.鈥?002/鈥媍bic.鈥?00800471 CrossRef
Guo JY et al (2008) Aven-dependent activation of ATM following DNA damage. Curr Biol CB 18:933鈥?42. doi:10.鈥?016/鈥媕.鈥媍ub.鈥?008.鈥?5.鈥?45 CrossRef PubMed
Hlavin EM, Smeaton MB, Miller PS (2010) Initiation of DNA interstrand cross-link repair in mammalian cells. Environ Mol Mutagen 51:604鈥?24. doi:10.鈥?002/鈥媏m.鈥?0559 PubMedCentral PubMed
Hodeify R, Tarcsafalvi A, Megyesi J, Safirstein RL, Price PM (2011) Cdk2-dependent phosphorylation of p21 regulates the role of Cdk2 in cisplatin cytotoxicity. Am J Physiol Ren Physiol 300:F1171鈥揊1179. doi:10.鈥?152/鈥媋jprenal.鈥?0507.鈥?010 CrossRef
Hurley PJ, Bunz F (2007) ATM and ATR: components of an integrated circuit. Cell Cycle 6:414鈥?17CrossRef PubMed
Jaamaa S et al (2010) DNA damage recognition via activated ATM and p53 pathway in nonproliferating human prostate tissue. Cancer Res 70:8630鈥?641. doi:10.鈥?158/鈥?008-5472.鈥婥AN-10-0937 CrossRef PubMed
Jackson PK (2013) Nek8 couples renal ciliopathies to DNA damage and checkpoint control. Mol Cell 51:407鈥?08. doi:10.鈥?016/鈥媕.鈥媘olcel.鈥?013.鈥?8.鈥?13 CrossRef PubMed
Jiang M, Dong Z (2008) Regulation and pathological role of p53 in cisplatin nephrotoxicity. J Pharmacol Exp Ther 327:300鈥?07. doi:10.鈥?124/鈥媕pet.鈥?08.鈥?39162 CrossRef PubMed
Jiang M, Wei Q, Wang J, Du Q, Yu J, Zhang L, Dong Z (2006) Regulation of PUMA-alpha by p53 in cisplatin-induced renal cell apoptosis. Oncogene 25:4056鈥?066. doi:10.鈥?038/鈥媠j.鈥媜nc.鈥?209440 CrossRef PubMed
Jiang M et al (2007) Nutlin-3 protects kidney cells during cisplatin therapy by suppressing Bax/Bak activation. J Biol Chem 282:2636鈥?645. doi:10.鈥?074/鈥媕bc.鈥婱606928200 PubMedCentral CrossRef PubMed
Jiang Z, Kamath R, Jin S, Balasubramani M, Pandita TK, Rajasekaran B (2011) Tip60-mediated acetylation activates transcription independent apoptotic activity of Abl. Mol Cancer 10:88. doi:10.鈥?186/鈥?476-4598-10-88 PubMedCentral CrossRef PubMed
Kang KP et al (2011) Luteolin ameliorates cisplatin-induced acute kidney injury in mice by regulation of p53-dependent renal tubular apoptosis. Nephrol Dial Transplant 26:814鈥?22. doi:10.鈥?093/鈥媙dt/鈥媑fq528 CrossRef PubMed
Kemp MG, Lindsey-Boltz LA, Sancar A (2011) The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA. J Biol Chem 286:19237鈥?9246. doi:10.鈥?074/鈥媕bc.鈥婱111.鈥?35036 PubMedCentral CrossRef PubMed
Kharbanda S et al (2000) Activation of MEK kinase 1 by the c-Abl protein tyrosine kinase in response to DNA damage. Mol Cell Biol 20:4979鈥?989PubMedCentral CrossRef PubMed
Kim WJ, Rajasekaran B, Brown KD (2007) MLH1- and ATM-dependent MAPK signaling is activated through c-Abl in response to the alkylator N-methyl-N鈥?nitro-N鈥?nitrosoguanidine. J Biol Chem 282:32021鈥?2031. doi:10.鈥?074/鈥媕bc.鈥婱701451200 CrossRef PubMed
Koike M, Mashino M, Sugasawa J, Koike A (2008) Histone H2AX phosphorylation independent of ATM after X-irradiation in mouse liver and kidney in situ. J Radiat Res 49:445鈥?49CrossRef PubMed
Kruger K, Thomale J, Stojanovic N, Osmak M, Henninger C, Bormann S, Fritz G (2015) Platinum-induced kidney damage: unraveling the DNA damage response (DDR) of renal tubular epithelial and glomerular endothelial cells following platinum injury. Biochim Biophys Acta 1854:685鈥?98. doi:10.鈥?016/鈥媕.鈥媌bamcr.鈥?014.鈥?2.鈥?33 CrossRef
Kutuk O, Temel SG, Tolunay S, Basaga H (2010) Aven blocks DNA damage-induced apoptosis by stabilising Bcl-xL. Eur J Cancer 46:2494鈥?505. doi:10.鈥?016/鈥媕.鈥媏jca.鈥?010.鈥?6.鈥?11 CrossRef PubMed
Lando DY, Chang CL, Fridman AS, Grigoryan IE, Galyuk EN, Hsueh YW, Hu CK (2014) Comparative thermal and thermodynamic study of DNA chemically modified with antitumor drug cisplatin and its inactive analog transplatin. J Inorg Biochem 137:85鈥?3. doi:10.鈥?016/鈥媕.鈥媕inorgbio.鈥?014.鈥?4.鈥?10 CrossRef PubMed
Levy D, Adamovich Y, Reuven N, Shaul Y (2007) The Yes-associated protein 1 stabilizes p73 by preventing Itch-mediated ubiquitination of p73. Cell Death Differ 14:743鈥?51. doi:10.鈥?038/鈥媠j.鈥媍dd.鈥?402063 CrossRef PubMed
Levy D, Adamovich Y, Reuven N, Shaul Y (2008) Yap1 phosphorylation by c-Abl is a critical step in selective activation of proapoptotic genes in response to DNA damage. Mol Cell 29:350鈥?61. doi:10.鈥?016/鈥媕.鈥媘olcel.鈥?007.鈥?2.鈥?22 CrossRef PubMed
Li GM (2008) Mechanisms and functions of DNA mismatch repair. Cell Res 18:85鈥?8. doi:10.鈥?038/鈥媍r.鈥?007.鈥?15 CrossRef PubMed
Livingston MJ, Dong Z (2014) Autophagy in acute kidney injury. Semin Nephrol 34:17鈥?6. doi:10.鈥?016/鈥媕.鈥媠emnephrol.鈥?013.鈥?1.鈥?04 PubMedCentral CrossRef PubMed
Lovejoy CA, Cortez D (2009) Common mechanisms of PIKK regulation. DNA Repair 8:1004鈥?008. doi:10.鈥?016/鈥媕.鈥媎narep.鈥?009.鈥?4.鈥?06 PubMedCentral CrossRef PubMed
Ma Z, Wei Q, Dong G, Huo Y, Dong Z (2014) DNA damage response in renal ischemia-reperfusion and ATP-depletion injury of renal tubular cells. Biochimica et Biophysica Acta 1842:1088鈥?096. doi:10.鈥?016/鈥媕.鈥媌badis.鈥?014.鈥?4.鈥?02 PubMedCentral CrossRef PubMed
Megyesi J, Safirstein RL, Price PM (1998) Induction of p21WAF1/CIP1/SDI1 in kidney tubule cells affects the course of cisplatin-induced acute renal failure. J Clin Investig 101:777鈥?82. doi:10.鈥?172/鈥婮CI1497 PubMedCentral CrossRef PubMed
Miller RP, Tadagavadi RK, Ramesh G, Reeves WB (2010) Mechanisms of Cisplatin nephrotoxicity. Toxins 2:2490鈥?518. doi:10.鈥?390/鈥媡oxins2112490 PubMedCentral CrossRef PubMed
Miyaji T, Kato A, Yasuda H, Fujigaki Y, Hishida A (2001) Role of the increase in p21 in cisplatin-induced acute renal failure in rats. J Am Soc Nephrol JASN 12:900鈥?08PubMed
Myers K, Gagou ME, Zuazua-Villar P, Rodriguez R, Meuth M (2009) ATR and Chk1 suppress a caspase-3-dependent apoptotic response following DNA replication stress. PLoS Genet 5:e1000324. doi:10.鈥?371/鈥媕ournal.鈥媝gen.鈥?000324 PubMedCentral CrossRef PubMed
Nakano K, Vousden KH (2001) PUMA, a novel proapoptotic gene, is induced by p53. Mol Cell 7:683鈥?94CrossRef PubMed
Nehme A, Baskaran R, Nebel S, Fink D, Howell SB, Wang JY, Christen RD (1999) Induction of JNK and c-Abl signalling by cisplatin and oxaliplatin in mismatch repair-proficient and -deficient cells. Br J Cancer 79:1104鈥?110. doi:10.鈥?038/鈥媠j.鈥媌jc.鈥?690176 PubMedCentral CrossRef PubMed
Oh GS, Kim HJ, Shen A, Lee SB, Khadka D, Pandit A, So HS (2014) Cisplatin-induced kidney dysfunction and perspectives on improving treatment strategies. Electrolyte Blood Press 12:55鈥?5. doi:10.鈥?049/鈥婨BP.鈥?014.鈥?2.鈥?.鈥?5 PubMedCentral CrossRef PubMed
Pabla N, Dong Z (2008) Cisplatin nephrotoxicity: mechanisms and renoprotective strategies. Kidney Int 73:994鈥?007. doi:10.鈥?038/鈥媠j.鈥媖i.鈥?002786 CrossRef PubMed
Pabla N, Dong Z (2012) Sibling rivalry in checkpoint control of cell cycle and DNA damage response. Cell Cycle 11:1866鈥?867. doi:10.鈥?161/鈥媍c.鈥?0416 CrossRef PubMed
Pabla N, Huang S, Mi QS, Daniel R, Dong Z (2008) ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis. J Biol Chem 283:6572鈥?583. doi:10.鈥?074/鈥媕bc.鈥婱707568200 CrossRef PubMed
Pabla N, Dong G, Jiang M, Huang S, Kumar MV, Messing RO, Dong Z (2011a) Inhibition of PKCdelta reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer. J Clin Investig 121:2709鈥?722. doi:10.鈥?172/鈥婮CI45586 PubMedCentral CrossRef PubMed
Pabla N, Ma Z, McIlhatton MA, Fishel R, Dong Z (2011b) hMSH2 recruits ATR to DNA damage sites for activation during DNA damage-induced apoptosis. J Biol Chem 286:10411鈥?0418. doi:10.鈥?074/鈥媕bc.鈥婱110.鈥?10989 PubMedCentral CrossRef PubMed
Pabla N, Bhatt K, Dong Z (2012) Checkpoint kinase 1 (Chk1)-short is a splice variant and endogenous inhibitor of Chk1 that regulates cell cycle and DNA damage checkpoints. Proc Natl Acad Sci USA 109:197鈥?02. doi:10.鈥?073/鈥媝nas.鈥?104767109 PubMedCentral CrossRef PubMed
Patil M, Pabla N, Ding HF, Dong Z (2013a) Nek1 interacts with Ku80 to assist chromatin loading of replication factors and S-phase progression. Cell Cycle 12:2608鈥?616. doi:10.鈥?161/鈥媍c.鈥?5624 PubMedCentral CrossRef PubMed
Patil M, Pabla N, Dong Z (2013b) Checkpoint kinase 1 in DNA damage response and cell cycle regulation. Cell Mol Life Sci CMLS 70:4009鈥?021. doi:10.鈥?007/鈥媠00018-013-1307-3 CrossRef PubMed
Paull TT, Lee JH (2005) The Mre11/Rad50/Nbs1 complex and its role as a DNA double-strand break sensor for ATM. Cell Cycle 4:737鈥?40CrossRef PubMed
Periyasamy-Thandavan S, Jiang M, Wei Q, Smith R, Yin XM, Dong Z (2008) Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells. Kidney Int 74:631鈥?40. doi:10.鈥?038/鈥媖i.鈥?008.鈥?14 CrossRef PubMed
Preyer M, Shu CW, Wang JY (2007) Delayed activation of Bax by DNA damage in embryonic stem cells with knock-in mutations of the Abl nuclear localization signals. Cell Death Differ 14:1139鈥?148. doi:10.鈥?038/鈥媠j.鈥媍dd.鈥?402119 CrossRef PubMed
Price PM, Megyesi J, Saf Irstein RL (2004a) Cell cycle regulation: repair and regeneration in acute renal failure. Kidney Int 66:509鈥?14. doi:10.鈥?111/鈥媕.鈥?523-1755.鈥?004.鈥?61_鈥?.鈥媥 CrossRef PubMed
Price PM, Safirstein RL, Megyesi J (2004b) Protection of renal cells from cisplatin toxicity by cell cycle inhibitors. Am J Physiol Ren Physiol 286:F378鈥揊384. doi:10.鈥?152/鈥媋jprenal.鈥?0192.鈥?003 CrossRef
Price PM, Yu F, Kaldis P, Aleem E, Nowak G, Safirstein RL, Megyesi J (2006) Dependence of cisplatin-induced cell death in vitro and in vivo on cyclin-dependent kinase 2. J Am Soc Nephrol JASN 17:2434鈥?442. doi:10.鈥?681/鈥婣SN.鈥?006020162 CrossRef PubMed
Price PM, Safirstein RL, Megyesi J (2009) The cell cycle and acute kidney injury. Kidney Int 76:604鈥?13. doi:10.鈥?038/鈥媖i.鈥?009.鈥?24 PubMedCentral CrossRef PubMed
Roos WP, Kaina B (2013) DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis. Cancer Lett 332:237鈥?48. doi:10.鈥?016/鈥媕.鈥媍anlet.鈥?012.鈥?1.鈥?07 CrossRef PubMed
Sahu BD, Kuncha M, Sindhura GJ, Sistla R (2013) Hesperidin attenuates cisplatin-induced acute renal injury by decreasing oxidative stress, inflammation and DNA damage. Phytomed Int J Phytother Phytopharmacol 20:453鈥?60. doi:10.鈥?016/鈥媕.鈥媝hymed.鈥?012.鈥?2.鈥?01 CrossRef
Sanchez-Prieto R, Sanchez-Arevalo VJ, Servitja JM, Gutkind JS (2002) Regulation of p73 by c-Abl through the p38 MAP kinase pathway. Oncogene 21:974鈥?79. doi:10.鈥?038/鈥媠j.鈥媜nc.鈥?205134 CrossRef PubMed
Seth R, Yang C, Kaushal V, Shah SV, Kaushal GP (2005) p53-dependent caspase-2 activation in mitochondrial release of apoptosis-inducing factor and its role in renal tubular epithelial cell injury. J Biol Chem 280:31230鈥?1239. doi:10.鈥?074/鈥媕bc.鈥婱503305200 CrossRef PubMed
Shimodaira H, Yoshioka-Yamashita A, Kolodner RD, Wang JY (2003) Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin. Proc Natl Acad Sci USA 100:2420鈥?425. doi:10.鈥?073/鈥媝nas.鈥?438031100 PubMedCentral CrossRef PubMed
Silva BA, Stambaugh JR, Yokomori K, Shah JV, Berns MW (2014) DNA damage to a single chromosome end delays anaphase onset. J Biol Chem 289:22771鈥?2784. doi:10.鈥?074/鈥媕bc.鈥婱113.鈥?35955 PubMedCentral CrossRef PubMed
Sridevi P, Nhiayi MK, Wang JY (2013) Genetic disruption of Abl nuclear import reduces renal apoptosis in a mouse model of cisplatin-induced nephrotoxicity. Cell Death Differ 20:953鈥?62. doi:10.鈥?038/鈥媍dd.鈥?013.鈥?2 PubMedCentral CrossRef PubMed
Stojic L, Brun R, Jiricny J (2004) Mismatch repair and DNA damage signalling. DNA Repair 3:1091鈥?101. doi:10.鈥?016/鈥媕.鈥媎narep.鈥?004.鈥?6.鈥?06 CrossRef PubMed
Tang J, Wang JY, Parker LL (2012) Detection of early Abl kinase activation after ionizing radiation by using a peptide biosensor. Chembiochem Eur J Chem Biol 13:665鈥?73. doi:10.鈥?002/鈥媍bic.鈥?01100763 CrossRef
Thomasova D, Anders HJ (2014) Cell cycle control in the kidney. Nephrol Dial Transplant. doi:10.鈥?093/鈥媙dt/鈥媑fu395 PubMed
Toh WH, Siddique MM, Boominathan L, Lin KW, Sabapathy K (2004) c-Jun regulates the stability and activity of the p53 homologue, p73. J Biol Chem 279:44713鈥?4722. doi:10.鈥?074/鈥媕bc.鈥婱407672200 CrossRef PubMed
Topping RP, Wilkinson JC, Scarpinato KD (2009) Mismatch repair protein deficiency compromises cisplatin-induced apoptotic signaling. J Biol Chem 284:14029鈥?4039. doi:10.鈥?074/鈥媕bc.鈥婱809303200 PubMedCentral CrossRef PubMed
Tsuruya K et al (2008) Involvement of p53-transactivated Puma in cisplatin-induced renal tubular cell death. Life Sci 83:550鈥?56. doi:10.鈥?016/鈥媕.鈥媗fs.鈥?008.鈥?8.鈥?02 CrossRef PubMed
Vasquez KM (2010) Targeting and processing of site-specific DNA interstrand crosslinks. Environ Mol Mutagen 51:527鈥?39. doi:10.鈥?002/鈥媏m.鈥?0557 PubMedCentral PubMed
Wang JY (2000) Regulation of cell death by the Abl tyrosine kinase. Oncogene 19:5643鈥?650. doi:10.鈥?038/鈥媠j.鈥媜nc.鈥?203878 CrossRef PubMed
Wang D, Lippard SJ (2005) Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov 4:307鈥?20. doi:10.鈥?038/鈥媙rd1691 CrossRef PubMed
Wang J, Pabla N, Wang CY, Wang W, Schoenlein PV, Dong Z (2006) Caspase-mediated cleavage of ATM during cisplatin-induced tubular cell apoptosis: inactivation of its kinase activity toward p53. Am J Physiol Ren Physiol 291:F1300鈥揊1307. doi:10.鈥?152/鈥媋jprenal.鈥?0509.鈥?005 CrossRef
Wang J et al (2013) Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation inhibition. Cell Death Dis 4:e699. doi:10.鈥?038/鈥媍ddis.鈥?013.鈥?27 PubMedCentral CrossRef PubMed
Wei Q, Dong G, Yang T, Megyesi J, Price PM, Dong Z (2007) Activation and involvement of p53 in cisplatin-induced nephrotoxicity. Am J Physiol Ren Physiol 293:F1282鈥揊1291. doi:10.鈥?152/鈥媋jprenal.鈥?0230.鈥?007 CrossRef
Woods D, Turchi JJ (2013) Chemotherapy induced DNA damage response: convergence of drugs and pathways. Cancer Biol Ther 14:379鈥?89. doi:10.鈥?161/鈥媍bt.鈥?3761 PubMedCentral CrossRef PubMed
Yoshida K (2008) Nuclear trafficking of pro-apoptotic kinases in response to DNA damage. Trends Mol Med 14:305鈥?13. doi:10.鈥?016/鈥媕.鈥媘olmed.鈥?008.鈥?5.鈥?03 CrossRef PubMed
Yoshida K, Miki Y (2005) Enabling death by the Abl tyrosine kinase: mechanisms for nuclear shuttling of c-Abl in response to DNA damage. Cell Cycle 4:777鈥?79CrossRef PubMed
Yuan M, Luong P, Hudson C, Gudmundsdottir K, Basu S (2010) c-Abl phosphorylation of DeltaNp63alpha is critical for cell viability. Cell Death Dis 1:e16. doi:10.鈥?038/鈥媍ddis.鈥?009.鈥?5 PubMedCentral CrossRef PubMed
Zannini L, Delia D, Buscemi G (2014) CHK2 kinase in the DNA damage response and beyond. J Mol Cell Biol 6:442鈥?57. doi:10.鈥?093/鈥媕mcb/鈥媘ju045 PubMedCentral CrossRef PubMed
Zhang YX et al (2013) Cisplatin upregulates MSH2 expression by reducing miR-21 to inhibit A549 cell growth. Biomed Pharmacother 67:97鈥?02. doi:10.鈥?016/鈥媕.鈥媌iopha.鈥?012.鈥?1.鈥?08 PubMedCentral CrossRef PubMed
Zhang D, Liu Y, Wei Q, Huo Y, Liu K, Liu F, Dong Z (2014) Tubular p53 regulates multiple genes to mediate AKI. J Am Soc Nephrol JASN 25:2278鈥?289. doi:10.鈥?681/鈥婣SN.鈥?013080902 CrossRef PubMed
Zhou H et al (2004) The induction of cell cycle regulatory and DNA repair proteins in cisplatin-induced acute renal failure. Toxicol Appl Pharmacol 200:111鈥?20. doi:10.鈥?016/鈥媕.鈥媡aap.鈥?004.鈥?4.鈥?03 CrossRef PubMed - 作者单位：Shiyao Zhu (1)
Navjotsingh Pabla (2)
Chengyuan Tang (1)
Liyu He (1)
Zheng Dong (1) (3)
1. Department of Nephrology, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China
2. Departments of Pharmaceutical Sciences, St. Jude Children鈥檚 Research Hospital, Memphis, TN, 38105, USA
3. Department of Cellular Biology and Anatomy, Medical College of Georgia at Georgia Regents University and Charlie Norwood VA Medical Center, 1459 Laney Walker Blvd, Augusta, GA, 30912, USA - 刊物主题：Pharmacology/Toxicology; Occupational Medicine/Industrial Medicine; Environmental Health; Biomedicine general;
- 出版者：Springer Berlin Heidelberg
- ISSN：1432-0738
文摘
Cisplatin and its derivatives are widely used chemotherapeutic drugs for cancer treatment. However, they have debilitating side effects in normal tissues and induce ototoxicity, neurotoxicity, and nephrotoxicity. In kidneys, cisplatin preferentially accumulates in renal tubular cells causing tubular cell injury and death, resulting in acute kidney injury (AKI). Recent studies have suggested that DNA damage and the associated DNA damage response (DDR) are an important pathogenic mechanism of AKI following cisplatin treatment. Activation of DDR may lead to cell cycle arrest and DNA repair for cell survival or, in the presence of severe injury, kidney cell death. Modulation of DDR may provide novel renoprotective strategies for cancer patients undergoing cisplatin chemotherapy. Keywords Cisplatin Nephrotoxicity Apoptosis Kidney DNA damage P53