Wls promotes the proliferation of breast cancer cells via Wnt signaling

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• 作者：Dong Lu (1) (2)
  Ying Li (3)
  Qing-Ru Liu (4)
  Qi Wu (5)
  Hao Zhang (5)
  Peng Xie (5)
  Qingling Wang (6)
  
  1. Department of Neurosurgery ; Affiliated Hospital of Xuzhou Medical College ; 99 West Huai-hai Road ; Xuzhou ; 221002 ; Jiangsu ; People鈥檚 Republic of China
  2. Lab of Neurosurgery ; Xuzhou Medical College ; Xuzhou ; Jiangsu ; People鈥檚 Republic of China
  3. Department of General Surgery ; Affiliated Hospital of Xuzhou Medical College ; 99 West Huai-hai Road ; Xuzhou ; 221002 ; Jiangsu ; People鈥檚 Republic of China
  4. Department of Pathology ; Affiliated Hospital of Xuzhou Medical College ; 99 West Huai-hai Road ; Xuzhou ; 221002 ; Jiangsu ; People鈥檚 Republic of China
  5. The Graduate School ; Xuzhou Medical College ; Xuzhou ; Jiangsu ; People鈥檚 Republic of China
  6. Department of Pathology ; Xuzhou Medical College ; Xuzhou ; 221004 ; People鈥檚 Republic of China
  
• 关键词：Wls ; Wnt ; 尾 ; Catenin ; Proliferation ; Breast cancer cells
• 刊名：Medical Oncology
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：32
• 期：5
• 全文大小：3,779 KB
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• 刊物主题：Oncology; Hematology; Pathology; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-131X

文摘

The Wnt secretion protein Wntless (Wls)/GPR177 has been reported to be involved in the development of several human cancers. However, the biological significance of Wls in breast cancer progression has not been clarified. In this study, we show for the first time that Wls is an important molecule related to breast cancer. We find that Wls expression is markedly increased in clinical breast tumors compared with adjacent noncancerous tissues. Downregulation of Wls by short-hairpin RNA severely suppressed the proliferation of breast cancer cells. Wls is a core Wnt signaling component, and we show that knockdown of Wls is sufficient to inhibit Wnt secretion and its downstream signaling. Taken together, these results indicate that Wls contributes to the proliferation of breast cancer cells by regulating Wnt signaling. Therefore, Wls could be a novel therapeutic target for inhibiting cell growth in breast cancer.