Neogenin expression is inversely associated with breast cancer grade in ex vivo

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• 作者：Wanying Xing (1)
  Qiang Li (2)
  Rangjuan Cao (2)
  Zheli Xu (1)
  
  1. Department of Breast Surgery ; China-Japan Union Hospital of Jilin University ; Changchun ; 130033 ; China
  2. Department of Hand Surgery ; China-Japan Union Hospital of Jilin University ; Changchun ; 130033 ; China
  
• 关键词：Neogenin ; breast cancer ; histological grading ; predictive biomarkers
• 刊名：World Journal of Surgical Oncology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：12
• 期：1
• 全文大小：569 KB
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• 刊物主题：Surgical Oncology;
• 出版者：BioMed Central
• ISSN：1477-7819

文摘

Background Neogenin is closely related to the human tumor suppressor gene deleted in colorectal cancer and plays a role in mammary morphogenesis. This study aimed to assess neogenin expression in breast cancer for any clinically significant association. Methods A total of 54 breast cancer patients who underwent modified radical mastectomy were enrolled for immunohistochemical and quantitative real-time PCR analysis of neogenin expression in their cancerous breast tissues in comparison to matching distant non-cancerous tissues. Results The data showed that the neogenin protein was either strongly or moderately expressed in the cytoplasm of the distant non-cancerous cells. In contrast, neogenin protein was either weakly or not expressed in the cytoplasm of 51/54 (94.4%) breast cancer cells, among which 13 breast cancer cases did not express neogenin protein at all (13/54, 24.1%). Similarly, levels of neogenin mRNA were significantly lower in breast cancer tissues than that of the matched distant non-cancerous tissues (51/54, 94.4%). Neogenin expression was inversely associated with breast cancer grade; that is, grade III breast cancer expressed much less neogenin than grade I-II (P Conclusions This study indicates that neogenin expression in breast cancer tissues is inversely associated with tumor grade.