Nanopore-based sensing and analysis: beyond the resistive-pulse method

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• 作者：Yanan Jiang (1)
  Wei Guo (2)
  
  1. Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education ; School of Chemistry and Environment ; Beihang University ; Beijing ; 100191 ; China
  2. Laboratory of Bio-Inspired Smart Interface Science ; Technical Institute of Physics and Chemistry ; Chinese Academy of Sciences ; Beijing ; 100190 ; China
  
• 关键词：Nanopore ; Sensing ; Stimuli response ; Steady state ; Transient signal
• 刊名：Chinese Science Bulletin
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：60
• 期：5
• 页码：491-502
• 全文大小：3,491 KB
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• 刊物主题：Science, general; Life Sciences, general; Physics, general; Chemistry/Food Science, general; Earth Sciences, general; Engineering, general;
• 出版者：Springer Berlin Heidelberg
• ISSN：1861-9541

文摘

Solid-state nanopores are generally considered as an indispensable element in the research field of fundamental ion transport and molecular sensing. The improvement in fabrication and chemical modification of the solid-state nanopores remains increasingly updated. During the last decades, numerous works have been reported on the nanopore-based sensing applications. More and more new analytical methods using nanopore-based devices are emerging. In this review, we highlight the recent progress on the analytical methods for the interdisciplinary and fast-growing area of nanopore research. According to the different types of the electrical readout, whether it is steady-state ionic current or transient current fluctuation, the nanopore-based sensing and analysis can be generally divided into two categories. For the first type, the electrical readout shows a stable blockade or reopening of the nanopore conductance in the presence of target analytes, termed steady-state analysis, including the conductance change, electrochemical analysis, and two-dimensional scanning and imaging. The other type is based on the transient fluctuation in the transmembrane ionic current, termed transient-state analysis, including the noise analysis, transient ion transport, and transverse tunneling current. The investigation of solid-state nanopores for chemical sensing is just in its infancy. For further research work, not only new nanopore materials and chemical modifications are needed, but also other non-electric-based sensing techniques should be developed. We will focus our future research in the framework of bio-inspired, smart, multiscale interfacial materials and extend the spirit of binary cooperative complementary nanomaterials.