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Ground-based platforms for space radiation research at the Institute of Modern Physics
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  • 作者:Dan Xu (1)
    Tingting Liu (1)
    He Li (1)
    Junrui Hua (1)
    Xin Zhao (2)
    Ning Tian (3)
    Jufang Wang (1)
    Guangming Zhou (1)
  • 关键词:Heavy ions ; Ground ; based platform ; Space radiation ; Biological effects
  • 刊名:Rendiconti Lincei
  • 出版年:2014
  • 出版时间:March 2014
  • 年:2014
  • 卷:25
  • 期:1-supp
  • 页码:13-16
  • 全文大小:554 KB
  • 参考文献:1. Cucinotta FA, Durante M (2006) Cancer risk from exposure to galactic cosmic rays: implications for space exploration by human beings. Lancet Oncol 7:431鈥?35 CrossRef
    2. Cucinotta FA, Hu S, Schwadron NA, Kozarev K, Townsend LW, Kim MHY (2010) Space radiation risk limits and Earth-Moon-Mars environmental models. Space Weather 8(12)
    3. Ding N, Pei H, He J, Furusawa Y, Hirayama R, Liu C, Matsumoto Y, Li H, Hu W, Li Y, Wang J, Wang T, Zhou G (2013) Simulated studies on the biological effects of space radiation on quiescent human fibroblasts. Adv Space Res 52:1314鈥?319 CrossRef
    4. Durante M, Cucinotta FA (2008) Heavy ion carcinogenesis and human space exploration. Cancer 8:465鈥?72
    5. Durante M, Cucinotta FA (2011) Physical basis of radiation protection in space travel [J]. Rev Mod Phys 83(4):1245 CrossRef
    6. Hei TK, Zhou H, Ivanov VN, Hong M, Lieberman HB, Brenner DJ, Amundson SA, Geard CR (2008) Mechanism of radiation-induced bystander effects: a unifying model. J Pharm Pharmacol 60:943鈥?50 CrossRef
    7. Hellweg CE, Kham CB (2007) Getting ready for the manned mission to Mars: the astronauts鈥?risk from space radiation. Naturwissenschaften 94:517鈥?26 CrossRef
    8. Ishikawa H, Ohno T, Kato S, Wakatsuki M, Iwakawa M, Ohta T et al (2012) Status of ion sources at National Institute of Radiological Sciences. Rev Sci Instrum 83(2):02A332
    9. Kim MY, Angelis GD, Cucinante FA (2011) Probabilistic assessment of radiation risk for astronauts in space missions. Acta Astron 68:747鈥?59 CrossRef
    10. Lloyd SA, Bandstra ER, Willey JS, Riffle SE, Tirado-Lee L, Nelson GA et al (2012) Effect of proton irradiation followed by hindlimb unloading on bone in mature mice: a model of long-duration spaceflight. Bone 51(4):756鈥?64 CrossRef
    11. Lowenstein DI (2000) BNL accelerator-based radiobiology facilities. Brookhaven National Lab., Upton, NY (US)
    12. Shay JW, Cucinotta FA, Sulzman FM (2011) From mice and men to earth and space: joint NASA-NCI workshop on lung cancer risk resulting from space and terrestrial radiation. Cancer Res 71:6926鈥?932 CrossRef
    13. Wang F, Bing Z, Zhang Y, Ao B, Zhang S, Ye C, He J, Ding N, Ye W, Xiong J, Sun J, Furusawa Y, Zhou G, Yang L (2013a) Quantitative proteomic analysis for radiation-induced cell cycle suspension in 92-1 melanoma cell line. J Radiat Res 1鈥?4
    14. Wang J, He J, Su F, Ding N, Hu W, Yao B, Wang W, Zhou G (2013b) Repression of ATR pathway by miR-185 enhances radiation-induced apoptosis and proliferation inhibition. Cell Death Disease 4:e699 CrossRef
    15. Wei BW (1989) Results from Lanzhou K450 heavy ion cyclotron. In: Proceedings of 1989 Particle Accelerators Conference, IEEE
    16. Wei BW (1993) HIRFL heavy ion cooler-storage ring proposal. In: Proceedings of the Fifth China鈥揓apan Joint Symposium on Accelerators for Nuclear Science and Their Applications, Osaka, Japan, pp 162
    17. Williams JR (1999) Predicting cancer rates in astronauts from animal carcinogenesis studies and cellular markers. Mutat Res 430:255鈥?69 CrossRef
    18. Xia JW, Rao YN, Yuan YJ, Wei BW (1996) HIRFL-CSR plan. In: Proceedings of the Sixth China鈥揓apan Joint Symposium on Accelerators for Nuclear Science and Their Applications, Chengdu, China, pp 24
    19. Xia JW, Wang YF, Rao YN, Yuan YJ, Song MT, Zhang WZ, Watanabe S (1998) HIRFL STATUS and HIRFL-CSR project in Lanzhou. In: Proceedings of the First Asian Particle Accelerators Conference, KEK, Japan, pp 342
    20. Xia JW, Zhan WL, Wei BW et al (2002) The heavy ion cooler-storage-ring project (HIRFL-CSR) at Lanzhou. NIM(A) 488(1):11鈥?5
    21. Ye C, Zhang X, Wan J, Chang L, Bing Z, Zhang S, Li J, He J, Wang J, Zhou G (2013) Long-term G2-arrested cells exposed to ionizing radiation undergo cellular senescence via slipping into the G1 phase. Cell Cycle 12(9):1424鈥?432 CrossRef
  • 作者单位:Dan Xu (1)
    Tingting Liu (1)
    He Li (1)
    Junrui Hua (1)
    Xin Zhao (2)
    Ning Tian (3)
    Jufang Wang (1)
    Guangming Zhou (1)

    1. Department of Space Radiobiology, Institute of Modern Physics, Chinese Academy of Sciences, Nanchang road No. 509, Lanzhou, 730000, China
    2. Institution of Genetics, School of Basic Medical Sciences, Lanzhou University, Lanzhou, 730000, China
    3. College of Pharmacy, Lanzhou University, Lanzhou, 730000, China
  • ISSN:1720-0776
文摘
Highly energized particles deliver ionizing radiation of galactic cosmic rays as well as solar particle events is a severe risk to the crews in long-term space missions. Two ground-based heavy ion experiment platforms simulating radiation environment of outer space have been established at the Institute of Modern Physics (IMP), Chinese Academy of Sciences. One task of the Department of Space Radiobiology is to manage the platforms and provide support to the experimental studies carried out on the platforms. The other one is to conduct basic studies on space radiobiology to establish accurate risk assessment models of space radiation and develop efficient countermeasures for the long-term exploration in deep space.

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