The update of anthocyanins on obesity and type 2 diabetes: Experimental evidence and clinical perspectives

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• 作者：Honghui Guo (1)
  Wenhua Ling (2)
  
  1. Department of Nutrition ; Henry Fok School of Food Science and Engineering ; Shaoguan University ; Shaoguan ; 512005 ; China
  2. Guangdong Provincial Key Laboratory of Food ; Nutrition and Health ; Department of Nutrition ; School of Public Health ; Sun Yat-Sen University (Northern Campus) ; Guangzhou ; 510080 ; China
  
• 关键词：Anthocyanin ; Inflammation ; Obesity ; Oxidative stress ; Type 2 diabetes mellitus
• 刊名：Reviews in Endocrine & Metabolic Disorders
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：16
• 期：1
• 页码：1-13
• 全文大小：491 KB
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• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Diabetes
  Internal Medicine
  
• 出版者：Springer Netherlands
• ISSN：1573-2606

文摘

With the dramatically increasing prevalence of obesity and type 2 diabetes mellitus (T2DM) worldwide, there is an urgent need for new strategies to combat the growing epidemic of these metabolic diseases. Diet is an essential factor affecting the development of and risk for obesity and T2DM and it can either help or hurt. In searching for preventative and therapeutic strategies, it is therefore advantageous to consider the potential of certain foods and their bioactive compounds to reverse or prevent the pathogenic processes associated with metabolic disease. Anthocyanins are naturally occurring polyphenolic compounds abundant in dark-colored fruits, vegetables and grains. Epidemiological studies suggest that increased consumption of anthocyanins lowers the risk of T2DM. Many in vitro and in vivo studies also reveal an array of mechanisms through which anthocyanins could prevent or reverse obesity- and T2DM-related pathologies including promotion of antioxidant and anti-inflammatory activities, improvement of insulin resistance, and hypolipidemic and hypoglycemic actions. Here, we summarize the data on anthocyanin-mediated protection against obesity and T2DM and the underlying mechanisms. Further population-based and long-term human intervention studies are necessary to ultimately evaluate the use of anthocyanins for protection/prevention against the development of obesity and T2DM.