Human uridine phosphorylase-1 inhibitors: a new approach to ameliorate 5-fluorouracil-induced intestinal mucositis
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- 作者：Daiana Renck (1) (2)
André A. Santos Jr (2) (3)
Pablo Machado (1) (2)
Guilherme O. Petersen (1) (2)
Tiago G. Lopes (4)
Diógenes S. Santos (1) (2)
Maria M. Campos (3) (5)
Luiz A. Basso (1) (2) - 关键词：5 ; fluorouracil ; Mucositis ; Uridine ; Human uridine phosphorylase ; 1 inhibitors
- 刊名：Investigational New Drugs
- 出版年：2014
- 出版时间：December 2014
- 年：2014
- 卷：32
- 期：6
- 页码：1301-1307
- 全文大小：768 KB
- 参考文献：1. Heidelberger C, Chaudhuri NK, Danneberg P, Mooren D, Griesbach L, Duschinsky R, Schnitzer RJ, Pleven E, Scheiner J (1957) Fluorinated pyrimidines, a new class of tumour-inhibitory compounds. Nature 179:663-66 CrossRef
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3. Grem JL (2000) 5-fluorouracil: forty-plus and still ticking. A review of its preclinical and clinical development. Invest New Drugs 18:299-13 CrossRef
4. van Groeningen CJ, Peters GJ, Pinedo HM (1992) Modulation of fluorouracil toxicity with uridine. Semin Oncol 19:148-54
5. Soares PMG, Mota JMSC, Gomes AS, Oliveira RB, Assreuy AMS, Brito GAC, Santos AA, Ribeiro RA, Souza MHLP (2008) Gastrointestinal dysmotility in 5-fluorouracil-induced intestinal mucositis outlasts inflammatory process resolution. Cancer Chemother Pharmacol 63:91-8 CrossRef
6. Rubenstein EB, Peterson DE, Schubert M, Keefe D, Mcguire D, Epstein J, Elting LS, Fox PC, Cooksley C, Sonis ST (2004) Clinical practice guidelines for the prevention and treatment of cancer therapy-induced oral and gastrointestinal mucositis. Cancer 100:2026-046 CrossRef
7. Sonis ST (2010) New thoughts on the initiation of mucositis. Oral Dis 16:597-00 CrossRef
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9. Huang TY, Chu HC, Lin YL, Ho WH, Hou HS, Chao YC, Liao CL (2009) Minocycline attenuates 5-fluorouracil-induced small intestinal mucositis in mouse model. Biochem Biophys Res Commun 389:634-39 CrossRef
10. Sonis ST (2009) Mucositis: the impact, biology and therapeutic opportunities of oral mucositis. Oral Oncol 45:1015-020 CrossRef
11. Bowen JM, Gibson RJ, Keefe DMK (2011) Animal models of mucositis: implications for therapy. J Support Oncol 9:161-68 CrossRef
12. Keefe DM, Schubert MM, Elting LS, Sonis ST, Epstein JB, Raber-Durlacher JE, Migliorati CA, McGuire DB, Hutchins RD, Peterson DE (2007) Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer 109:820-31 CrossRef
13. Melichar B, Kohout P, Bratova M, Solichova D, Kralickova P, Zadak Z (2001) Intestinal permeability in patients with chemotherapy-induced stomatitis. J Cancer Res Clin Oncol 127:314-18 CrossRef
14. Al Safarjalani ON, Rais R, Shi J, Schinazi RF, Naguib FNM, MH E k (2006) Modulation of 5-fluorouracil host-toxicity and chemotherapeutic efficacy against human colon tumors by 5-(Phenylthio) acyclouridine, a uridine phosphorylase inhibitor. Cancer Chemother Pharmacol 58:692-98 CrossRef
15. Leyva A, van Groeningen CJ, Kraal I, Gall H, Peter GJ, Lankelma J, Pinedo HM (1984) Phase I and Pharmacokinetic studies of high-dose uridine intended for rescue from 5-fluorouracil toxicity. Cancer Res 44:5928-933
16. Renck D, Machado P, Souto AA, Rosado LA, Erig T, Campos MM, Farias CB, Roesler R, Timmers LF, de Souza ON, Santos DS, Basso LA (2013) Design of novel potent inhibitors of human uridine phosphorylase-1: synthesis, inhibition studies, thermodynamics, and in vitro influence on 5-fluorouracil cytotoxicity. J Med Chem 56:8892-902 CrossRef
17. Al Safarjalani ON, Rais R, Naguib FNM, el Kouni MH (2012) Potent combination therapy for human breast tu - 作者单位：Daiana Renck (1) (2)
André A. Santos Jr (2) (3)
Pablo Machado (1) (2)
Guilherme O. Petersen (1) (2)
Tiago G. Lopes (4)
Diógenes S. Santos (1) (2)
Maria M. Campos (3) (5)
Luiz A. Basso (1) (2)
1. Centro de Pesquisas em Biologia Molecular e Funcional (CPBMF) Instituto Nacional de Ciência e Tecnologia em Tuberculose (INCT-TB), Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil
2. Programa de Pós-Gradua??o em Biologia Celular e Molecular, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil
3. Instituto de Toxicologia e Farmacologia, Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil
4. Instituto de Pesquisas Biomédicas (IPB), Pontifícia Universidade Católica do Rio Grande do Sul, Porto Alegre, RS, Brazil
5. Faculdade de Odontologia, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Porto Alegre, RS, Brazil - ISSN：1573-0646
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