Hyperuricemia and acute kidney injury secondary to spontaneous tumor lysis syndrome in low risk myelodysplastic syndrome

详细信息    查看全文

• 作者：Yunlin Feng (1)
  Tao Jiang (2)
  Li Wang (1)
  
  1. Division of Nephrology ; Sichuan Academy of Medical Sciences and Sichuan Provincial People鈥檚 Hospital ; Chengdu ; 610072 ; China
  2. Division of Hemotology ; Sichuan Academy of Medical Sciences and Sichuan Provincial People鈥檚 Hospital ; Chengdu ; 610072 ; China
  
• 关键词：Acute kidney injury ; Hyperuricemia ; Myelodysplastic syndrome ; Spontaneous tumor lysis syndrome
• 刊名：BMC Nephrology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：15
• 期：1
• 全文大小：269 KB
• 参考文献：1. Jasek, AM, Day, HJ (1994) Acute spontaneous tumor lysis syndrome. Am J Hematol 47: pp. 129-131 2/ajh.2830470212" target="_blank" title="It opens in new window">CrossRef
  2. Hsu, HH, Chen, YC, Tian, YC, Chan, YL, Kuo, MC, Tang, CC, Fang, JT, Lee, SY, Yang, CW (2009) Role of serum sodium in assessing hospital mortality in cancer patients with spontaneous tumor lysis syndrome inducing acute uric acid nephropathy. Int J Clin Pract 63: pp. 751-756 2-1241.2007.01264.x" target="_blank" title="It opens in new window">CrossRef
  3. Cairo, MS, Bishop, M (2004) Tumour lysis syndrome: new therapeutic strategies and classification. Br J Haematol 127: pp. 3-11 2141.2004.05094.x" target="_blank" title="It opens in new window">CrossRef
  4. Kobayashi, D, Wofford, M, McLean, TW, Lin, JJ (2010) Spontaneous tumor lysis syndromes in a child with T-cell acute lymphoblastic leukemia. Pediatr Blood Cancer 54: pp. 773-775
  5. Riccio, B, Mato, A, Olson, EM, Berns, JS, Luger, S (2006) Spontaneous tumor lysis syndrome in acute myeloid leukemia: two cases and a review of the literature. Cancer Biol Ther 5: pp. 1614-1617 2.3610" target="_blank" title="It opens in new window">CrossRef
  6. Sile, S, Wall, BM (2001) Acute renal failure secondary to spontaneous acute tumor lysis syndrome in myelofibrosis. Am J Kidney Dis 38: pp. E21 2001.27730" target="_blank" title="It opens in new window">CrossRef
  7. Pentheroudakis, G, O'Neill, VJ, Vasey, P, Kaye, SB (2001) Spontaneous acute tumor lysis syndrome in patients with metasitatic germ cell tumors. Report of two cases. Support Care Cancer 9: pp. 554-557 200100276" target="_blank" title="It opens in new window">CrossRef
  8. Levin, M, Cho, S (1996) Acute tumor lysis syndrome in high grade lymphoblastic lymphoma after a prolonged episode of fever. Med Pediatr Oncol 216: pp. 417-418 2/(SICI)1096-911X(199606)26:6<417::AID-MPO9>3.0.CO;2-K" target="_blank" title="It opens in new window">CrossRef
  9. Yang, SS, Chau, T, Dai, MS, Lin, SH (2003) Steroid-induced tumor lysis syndrome in a patient with preleukemia. Clin Nephropathy 59: pp. 201-205 201" target="_blank" title="It opens in new window">CrossRef
  10. Chen, RL, Chuang, SS (2009) Transient spontaneous remission after tumor lysis syndrome trigged by a severe pulmonary infection in an adolescent boy with acute lymphoblastic leukemia. J Pediatr Hemotol Oncol 31: pp. 76-79 CrossRef
  11. Sharma, SK, Malhotra, P, Kumar, M, Sharma, A, Varma, N, Singh, S (2005) Spontaneous tumor lsis syndrome in acute lymphoblastic leukemia. J Assoc Physicians India 53: pp. 828-830
  12. The pre-publication history for this paper can be accessed here:2369/15/164/prepub" class="a-plus-plus">http://www.biomedcentral.com/1471-2369/15/164/prepub
  
• 刊物主题：Nephrology; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2369

文摘

Background This is a rare instance of acute kidney injury caused by hyperuricemia due to spontaneous tumor lysis syndrome and also the first case of spontaneous tumor lysis syndrome reported in association with myelodysplastic syndrome. Case presentation A 53-year-old man presented with abrupt oliguria. Laboratory findings on admission included hyperuricemia, hyperphosphatemia, hypocalcemia, metabolic acidosis and rapidly rising serum creatinine, which were consistent with acute tumor lysis syndrome in the absence of precipitating chemotherapy or radiotherapy. After hemodialysis and oral uric acid lowering therapy, serum uric acid levels returned to normal range and renal function rapidly recovered. The patient was diagnosed as myelodysplastic syndrome eleven months later. Conclusions Occult malignancy including solid tumors and hematological malignancies should be carefully evaluated in the case of unexplainable acute kidney injury with hyperuricemia. Aggressive investigations should be thoroughly considered and repeated in this population.