Plasma microRNA-103, microRNA-107, and microRNA-194 levels are not biomarkers for human diffuse gastric cancer

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• 作者：Isao Oze ; Shu Shimada ; Hiromi Nagasaki…
• 关键词：E ; cadherin ; Gastric cancer/PC ; MicroRNAs ; p53 genes
• 刊名：Journal of Cancer Research and Clinical Oncology
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：143
• 期：3
• 页码：551-554
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Oncology; Cancer Research; Internal Medicine; Hematology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-1335
• 卷排序：143

文摘

PurposeDiffuse-type gastric cancer (DGC) carries a poor prognosis. Effective screening is one measure that might improve the prognosis of this disease. An E-cadherin/p53 double-conditional knockout (DCKO) mouse line recapitulates human DGC morphologically and molecularly. Three circulating microRNAs (miRNA) (miR-103, miR-107, miR-194) in DCKO mice have been identified as biomarkers for DGC. We sought to evaluate whether these circulating miRNAs could be used for the detection of human DGC.