Possible sexually dimorphic role of miRNA and other sncRNA in ASD brain
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- 作者：Cynthia M. Schumann ; Frank R. Sharp ; Bradley P. Ander ; Boryana Stamova
- 关键词：Autism ; microRNA ; small noncoding RNA ; Superior Temporal Sulcus ; Auditory cortex ; Myelin ; Oligodendrocytes ; Sex ; Sexual dimorphism ; miR ; 181 ; miR ; 338 ; miR ; 219 ; miR ; 125 ; miR ; 448 ; Postmortem human brain
- 刊名：Molecular Autism
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：8
- 期：1
- 全文大小：2308KB
- 刊物主题：Neurology; Neurosciences; Neuropsychology; Psychiatry; Pediatrics; Human Genetics;
- 出版者：BioMed Central
- ISSN：2040-2392
- 卷排序：8
文摘
BackgroundAutism spectrum disorder (ASD) is sexually dimorphic in brain structure, genetics, and behaviors. In studies of brain tissue, the age of the population is clearly a factor in interpreting study outcome, yet sex is rarely considered. To begin to address this issue, we extend our previously published microarray analyses to examine expression of small noncoding RNAs (sncRNAs), including microRNAs (miRNAs), in ASD and in the control temporal cortex in males and females. Predicted miRNA targets were identified as well as the pathways they overpopulate.