Self-assembling peptide nanofiber hydrogels for central nervous system regeneration

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• 作者：Xi Liu (1) (2)
  Bin Pi (3)
  Hui Wang (1)
  Xiu-Mei Wang (2)
  
  1. National Engineering Laboratory for Modern Silk ; College of Textile and Clothing Engineering ; Soochow University ; Suzhou ; 215123 ; China
  2. Institute for Regenerative Medicine and Biomimetic Materials ; Key Laboratory of Advanced Materials ; School of Materials Science and Engineering ; Tsinghua University ; Beijing ; 100084 ; China
  3. Department of Orthopedics ; The First Affiliated Hospital of Soochow University ; Suzhou ; 215006 ; China
  
• 关键词：self ; assembling peptide ; hydrogel ; central nervous system (CNS) ; nerve regeneration
• 刊名：Frontiers of Materials Science
• 出版年：2015
• 出版时间：March 2015
• 年：2015
• 卷：9
• 期：1
• 页码：1-13
• 全文大小：842 KB
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• 刊物类别：Chemistry and Materials Science
• 刊物主题：Materials Science
  Chemistry
  Chinese Library of Science
  
• 出版者：Higher Education Press, co-published with Springer-Verlag GmbH
• ISSN：2095-0268

文摘

Central nervous system (CNS) presents a complex regeneration problem due to the inability of central neurons to regenerate correct axonal and dendritic connections. However, recent advances in developmental neurobiology, cell signaling, cell-matrix interaction, and biomaterials technologies have forced a reconsideration of CNS regeneration potentials from the viewpoint of tissue engineering and regenerative medicine. The applications of a novel tissue regeneration-inducing biomaterial and stem cells are thought to be critical for the mission. The use of peptide nanofiber hydrogels in cell therapy and tissue engineering offers promising perspectives for CNS regeneration. Self-assembling peptide undergo a rapid transformation from liquid to gel upon addition of counterions or pH adjustment, directly integrating with the host tissue. The peptide nanofiber hydrogels have mechanical properties that closely match the native central nervous extracellular matrix, which could enhance axonal growth. Such materials can provide an optimal three dimensional microenvironment for encapsulated cells. These materials can also be tailored with bioactive motifs to modulate the wound environment and enhance regeneration. This review intends to detail the recent status of self-assembling peptide nanofiber hydrogels for CNS regeneration.