Ozone oxidation of antidepressants in wastewater –Treatment evaluation and characterization of new by-products by LC-QToFMS

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• 作者：André Lajeunesse (1)
  Mireille Blais (2)
  Beno?t Barbeau (2)
  Sébastien Sauvé (3)
  Christian Gagnon (1)
  
• 关键词：Antidepressants ; Ozone ; LC ; MS/MS ; Sewage treatment plants ; Biosolids ; Side ; products
• 刊名：Chemistry Central Journal
• 出版年：2013
• 出版时间：December 2013
• 年：2013
• 卷：7
• 期：1
• 全文大小：497KB
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• 作者单位：André Lajeunesse (1)
  Mireille Blais (2)
  Beno?t Barbeau (2)
  Sébastien Sauvé (3)
  Christian Gagnon (1)
  
  1. Environment Canada, Wastewater and Effluents Section, Water Science and Technology Directorate, 105 McGill Street, Montreal, Quebec, H2Y 2E7, Canada
  2. école Polytechnique de Montréal, Department of Civil, Geological and Mining Engineering, P.O. Box 6079, Succursale Centre-ville, Montreal, Quebec, H3C 3A7, Canada
  3. Department of Chemistry, Université de Montréal, P.O. Box 6128, Succursale Centre-ville, Montreal, Quebec, H3C 3J7, Canada
  
• ISSN：1752-153X

文摘

Background The fate of 14 antidepressants along with their respective N-desmethyl metabolites and the anticonvulsive drug carbamazepine was examined in a primary sewage treatment plant (STP) and following advanced treatments with ozone (O3). The concentrations of each pharmaceutical compound were determined in raw sewage, effluent and sewage sludge samples by LC-MS/MS analysis. The occurrence of antidepressant by-products formed in treated effluent after ozonation was also investigated. Results Current primary treatments using physical and chemical processes removed little of the compounds (mean removal efficiency: 19%). Experimental sorption coefficients (Kd) of each studied compounds were also calculated. Sorption of venlafaxine, desmethylvenlafaxine, and carbamazepine on sludge was assumed to be negligible (log Kd ?2), but higher sorption behavior can be expected for sertraline (log Kd ?4). Ozonation treatment with O3 (5 mg/L) led to a satisfactory mean removal efficiency of 88% of the compounds. Screening of the final ozone-treated effluent samples by high resolution-mass spectrometry (LC-QqToFMS) did confirm the presence of related N-oxide by-products. Conclusion Effluent ozonation led to higher mean removal efficiencies than current primary treatment, and therefore represented a promising strategy for the elimination of antidepressants in urban wastewaters. However, the use of O3 produced by-products with unknown toxicity.