Association Between Blood Spot Transforming Growth Factor-β and Patent Ductus Arteriosus in Extremely Low-Birth Weight Infants
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- 作者：Girija Natarajan (1)
Seetha Shankaran (1)
Scott A. McDonald (2)
Abhik Das (3)
Richard A. Ehrenkranz (4)
Ronald N. Goldberg (5)
Barbara J. Stoll (6)
Jon E. Tyson (7)
Rosemary D. Higgins (8)
Diana Schendel (9)
David M Hougaard (10)
Kristin Skogstrand (10)
Poul Thorsen (11) (12)
Waldemar A. Carlo (13) - 关键词：Transforming growth factor ; Patent ductus arteriosus ; Preterm ; Neonate
- 刊名：Pediatric Cardiology
- 出版年：2013
- 出版时间：January 2013
- 年：2013
- 卷：34
- 期：1
- 页码：149-154
- 全文大小：247KB
- 参考文献：1. Ambalavanan N, Carlo WA, D’Angio CT, McDonald SA, Das A, Schendel D et al (2009) Cytokines associated with bronchopulmonary dysplasia or death in extremely low birth weight infants. Pediatrics 123:1132-141 CrossRef
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3. Carlo WA, McDonald SA, Tyson JE, Stoll BJ, Ehrenkranz RA, Shankaran S et al (2011) Cytokines and neurodevelopmental outcomes in extremely low birth weight infants. J Pediatr 159(6):919-25 CrossRef
4. Choi CW, Kim B, Joung KE, Lee JA, Lee YK, Kim EK et al (2008) Decreased expression of transforming growth factor-beta1 in bronchoalveolar lavage cells of preterm infants with maternal chorioamnionitis. J Korean Med Sci 23:609-15 CrossRef
5. Clyman RI, Seidner SR, Kajino H, Roman C, Koch CJ, Ferrara N et al (2002) VEGF regulates remodeling during permanent anatomic closure of the ductus arteriosus. Am J Physiol Regul Integr Comp Physiol 282:R199–R206
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13. Vento G, Matassa PG, Colnaghi MR, Ameglio F, Capoluongo E, Vendettuoli V et al (2007) Persistence of patency of ductus arteriosus in preterm infants: do VEGF and TGF B 1 play a role? [abstract]. E-PAS :615893.6
14. Yetman AT, Beroukhim RS, Ivy DD, Manchester D (2007) Importance of the clinical recognition of Loeys Dietz syndrome in the neonatal period. Pediatrics 119:e1199–e1202 CrossRef
15. Zhou B, Coulber C, Rabinovitch M (1998) Tissue-specific and developmental regulation of transforming growth factor-beta1 expression in fetal lamb ductus arteriosus endothelial cells. Pediatr Res 44:865-72 CrossRef - 作者单位：Girija Natarajan (1)
Seetha Shankaran (1)
Scott A. McDonald (2)
Abhik Das (3)
Richard A. Ehrenkranz (4)
Ronald N. Goldberg (5)
Barbara J. Stoll (6)
Jon E. Tyson (7)
Rosemary D. Higgins (8)
Diana Schendel (9)
David M Hougaard (10)
Kristin Skogstrand (10)
Poul Thorsen (11) (12)
Waldemar A. Carlo (13)
1. Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI, 48201, USA
2. Department of Statistics and Epidemiology, RTI International, Research Triangle Park, Durham, NC, USA
3. Department of Statistics and Epidemiology, RTI International, Rockville, MD, USA
4. Department of Pediatrics, Yale University School of Medicine, New Haven, CT, USA
5. Department of Pediatrics, Duke University, Durham, NC, USA
6. Department of Pediatrics, Emory University, Atlanta, GA, USA
7. Department of Pediatrics, University of Texas Medical School at Houston, Houston, TX, USA
8. Eunice Kennedy Shriver National Institute of Child Health and Human Development, Bethesda, MD, USA
9. National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GA, USA
10. Section of Neonatal Screening and Hormones, Department of Clinical Biochemistry and Immunology, Statens Serum Institut, 2300, Copenhagen, Denmark
11. Department of Obstetrics and Gynecology, Lillebaelt Hospital, Kolding, Denmark
12. Rollins School of Public Health, Emory University, Atlanta, GA, USA
13. Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL, USA - ISSN：1432-1971
文摘
Permanent ductal closure involves anatomic remodeling, in which transforming growth factor (TGF)-β appears to play a role. Our objective was to evaluate the relationship, if any, between blood spot TGF-β on day 3 and day 7 of life and patent ductus arteriosus (PDA) in extremely low birth weight (ELBW) infants. Prospective observational study involving ELBW infants (n?=?968) in the National Institute of Child Health and Human Development Neonatal Research Network who had TGF-β measured on filter paper spot blood samples using a Luminex assay. Infants with a PDA (n?=?493) were significantly more immature, had lower birth weights, and had higher rates of respiratory distress syndrome than those without PDA (n?=?475). TGF-β on days 3 and 7 of life, respectively, were significantly lower among neonates with PDA (median 1,177?pg/ml [range 642-,896]; median 1,386?pg/ml [range 868-,913]) compared with others without PDA (median 1,334?pg/ml [range 760-,064]; median 1,712?pg/ml [range 1,014-,518?pg/ml]). The significant difference persisted when death or PDA was considered a composite outcome. TGF-β levels were not significantly different among subgroups of infants with PDA who were not treated (n?=?51) versus those who were treated medically (n?=?283) or by surgical ligation (n?=?159). TGF-β was not a significant predictor of death or PDA (day 3 odds ratio [OR] 0.99, 95?% confidence interval [CI] 0.83-.17; day 7 OR 0.88, 95?% CI 0.74-.04) on adjusted analyses. Our results suggest that blood spot TGF-β alone is unlikely to be a reliable biomarker of a clinically significant PDA or its responsiveness to treatment.