Electroacupuncture stimulation at sub-specific acupoint and non-acupoint induced distinct brain glucose metabolism change in migraineurs: a PET-CT study

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• 作者：Mingxiao Yang (1)
  Jie Yang (1)
  Fang Zeng (1)
  Peng Liu (2)
  Zhenhong Lai (1)
  Shufang Deng (1)
  Li Fang (3)
  Wenzhong Song (4)
  Hongjun Xie (4)
  Fanrong Liang (1)
  
  1. Acupuncture and Tuina School ; Chengdu University of Traditional Chinese Medicine ; Chengdu ; Sichuan ; China
  2. Life Science Research Center ; School of Life Science and Technology ; Xidian University ; Xi鈥檃n ; Shaanxi ; China
  3. Department of Acupuncture ; the Third Affiliated Hospital of Zhejiang University of TCM ; Hangzhou ; Zhejiang ; China
  4. PET-CT Center ; Sichuan Provincial People鈥檚 Hospital ; Chengdu ; Sichuan ; China
  
• 关键词：Acupuncture analgesia ; PEC ; CT ; Migraine
• 刊名：Journal of Translational Medicine
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：12
• 期：1
• 全文大小：1,773 KB
• 参考文献：1. Vickers, AJ, Cronin, AM, Maschino, AC, Lewith, G, MacPherson, H, Foster, NE, Sherman, KJ, Witt, CM, Linde, K, Collaboration, AT (2012) Acupuncture for chronic pain: individual patient data meta-analysis. Arch Intern Med 172: pp. 1444-1453 CrossRef
  2. Linde, K, Niemann, K, Schneider, A, Meissner, K (2010) How large are the nonspecific effects of acupuncture? A meta-analysis of randomized controlled trials. BMC Med 8: pp. 75 CrossRef
  3. Madsen, MV, G酶tzsche, PC, Hr贸bjartsson, A (2009) Acupuncture treatment for pain: systematic review of randomised clinical trials with acupuncture, placebo acupuncture, and no acupuncture groups. BMJ 338: pp. A3115 CrossRef
  4. Alecrim-Andrade, J, Maciel-J煤nior, JA, Carn猫, X, Vasconcelos, GMS, Correa-Filho, HR (2008) Acupuncture in migraine prevention: a randomized sham controlled study with 6-months posttreatmentFollow-up. Clin J Pain 24: pp. 98-105 CrossRef
  5. MacPherson, H, Maschino, AC, Lewith, G, Foster, NE, Witt, C, Vickers, AJ, Collaboration, AT (2013) Characteristics of acupuncture treatment associated with outcome: an individual patient meta-analysis of 17,922 patients with chronic pain in randomised controlled trials. PLoS One 8: pp. e77438 CrossRef
  6. Zhao, L, Chen, J, Liu, C-Z, Li, Y, Cai, D-J, Tang, Y, Yang, J, Liang, F-R (2012) A review of acupoint specificity research in China: status quo and prospects. Evid Based Complement Altern Med 2012: pp. 1-16
  7. Dhond, RP, Yeh, C, Park, K, Kettner, N, Napadow, V (2008) Acupuncture modulates resting state connectivity in default and sensorimotor brain networks. Pain 136: pp. 407-418 CrossRef
  8. Dhond, RP, Kettner, N, Napadow, V (2007) Neuroimaging acupuncture effects in the human brain. J Altern Complement Med 13: pp. 603-616 CrossRef
  9. Napadow, V, Kettner, N, Liu, J, Li, M, Kwong, K, Vangel, M, Makris, N, Audette, J, Hui, K (2007) Hypothalamus and amygdala response to acupuncture stimuli in carpal tunnel syndrome. Pain 130: pp. 254-266 CrossRef
  10. Bai, L, Qin, W, Tian, J, Dong, M, Pan, X, Chen, P, Dai, J, Yang, W, Liu, Y (2009) Acupuncture modulates spontaneous activities in the anticorrelated resting brain networks. Brain Res 1279: pp. 37-49 CrossRef
  11. Huang, W, Pach, D, Napadow, V, Park, K, Long, X, Neumann, J, Maeda, Y, Nierhaus, T, Liang, F, Witt, CM (2012) Characterizing acupuncture stimuli using brain imaging with fMRI-a systematic review and meta-analysis of the literature. PLoS One 7: pp. e32960 CrossRef
  12. Hui, KK, Liu, J, Marina, O, Napadow, V, Haselgrove, C, Kwong, KK, Kennedy, DN, Makris, N (2005) The integrated response of the human cerebro-cerebellar and limbic systems to acupuncture stimulation at ST 36 as evidenced by fMRI. Neuroimage 27: pp. 479-496 CrossRef
  13. Zhang, W-T, Jin, Z, Luo, F, Zhang, L, Zeng, Y-W, Han, J-S (2004) Evidence from brain imaging with fMRI supporting functional specificity of acupoints in humans. Neurosci Lett 354: pp. 50-53 CrossRef
  14. Campbell, A (2006) Point specificity of acupuncture in the light of recent clinical and imaging studies. Acupunct Med 24: pp. 118-122 CrossRef
  15. Huang, Y, Tang, C, Wang, S, Lu, Y, Shen, W, Yang, J, Chen, J, Lin, R, Cui, S, Xiao, H (2012) Acupuncture regulates the glucose metabolism in cerebral functional regions in chronic stage ischemic stroke patients鈥?a PET-CT cerebral functional imaging study. BMC Neurosci 13: pp. 75 CrossRef
  16. Zeng, F, Qin, W, Ma, T, Sun, J, Tang, Y, Yuan, K, Li, Y, Liu, J, Liu, X, Song, W, Lan, L, Liu, M, Yu, S, Gao, X, Tian, J, Liang, F (2012) Influence of acupuncture treatment on cerebral activity in functional dyspepsia patients and its relationship with efficacy. Am J Gastroenterol 107: pp. 1236-1247 CrossRef
  17. Hogeboom, C, Sherman, K, Cherkin, D (2001) Variation in diagnosis and treatment of chronic low back pain by traditional Chinese medicine acupuncturists. Complement Ther Med 9: pp. 154-166 CrossRef
  18. Vickers, AJ, Rees, RW, Zollman, CE, McCarney, R, Smith, CM, Ellis, N, Fisher, P, Haselen, R (2004) Acupuncture for chronic headache in primary care: large, pragmatic, randomised trial. BMJ 328: pp. 744 CrossRef
  19. Melchart, D, Thormaehlen, J, Hager, S, Liao, J, Linde, K, Weidenhammer, W (2003) Acupuncture versus placebo versus sumatriptan for early treatment of migraine attacks: a randomized controlled trial. J Intern Med 253: pp. 181-188 CrossRef
  20. Linde, K, Allais, G, Brinkhaus, B, Manheimer, E, Vickers, A, White, AR (2009) Acupuncture for migraine prophylaxis. Cochrane Database Syst Rev 1:
  21. Li, Y, Liang, F, Yang, X, Tian, X, Yan, J, Sun, G, Chang, X, Tang, Y, Ma, T, Zhou, L (2009) Acupuncture for treating acute attacks of migraine: a randomized controlled trial. Headache 49: pp. 805-816 CrossRef
  22. Wang, LP, Zhang, XZ, Guo, J, Liu, HL, Zhang, Y, Liu, CZ, Yi, JH, Wang, LP, Zhao, JP, Li, SS (2012) Efficacy of acupuncture for acute migraine attack: a multicenter single blinded, randomized controlled Trial. Pain Med 13: pp. 623-630 CrossRef
  23. Diener, H-C, Kronfeld, K, Boewing, G, Lungenhausen, M, Maier, C, Molsberger, A, Tegenthoff, M, Trampisch, H-J, Zenz, M, Meinert, R (2006) Efficacy of acupuncture for the prophylaxis of migraine: a multicentre randomised controlled clinical trial. Lancet Neurol 5: pp. 310-316 CrossRef
  24. Wang, LP, Zhang, XZ, Guo, J, Liu, HL, Zhang, Y, Liu, CZ, Yi, JH, Zhao, JP, Li, SS (2011) Efficacy of acupuncture for migraine prophylaxis: a single-blinded, double-dummy, randomized controlled trial. Pain 152: pp. 1864-1871 CrossRef
  25. Yang, J, Zeng, F, Feng, Y, Fang, L, Qin, W, Liu, X, Song, W, Xie, H, Chen, J, Liang, F (2012) A PET-CT study on the specificity of acupoints through acupuncture treatment in migraine patients. BMC Complement Altern Med 12: pp. 1472-6882
  26. Li, Y, Zheng, H, Witt, CM, Roll, S, Yu, S-G, Yan, J, Sun, G-J, Zhao, L, Huang, W-J, Chang, X-R (2012) Acupuncture for migraine prophylaxis: a randomized controlled trial. Can Med Assoc J 184: pp. 401-10 CrossRef
  27. Linde, K, Streng, A, J眉rgens, S, Hoppe, A, Brinkhaus, B, Witt, C, Wagenpfeil, S, Pfaffenrath, V, Hammes, MG, Weidenhammer, W (2005) Acupuncture for patients with migraine: a randomized controlled trial. JAMA 293: pp. 2118-2125 CrossRef
  28. Kong, J, Gollub, R, Huang, T, Polich, G, Napadow, V, Hui, K, Vangel, M, Rosen, B, Kaptchuk, TJ (2007) Acupuncture de qi, from qualitative history to quantitative measurement. J Altern Complement Med 13: pp. 1059-1070 CrossRef
  29. Yang, J, Yang, M-X, Zeng, F, Wu, X, Chen, J, Liu, Y-Q, Feng, Y, Liang, F-R (2013) Visualized characterization for cerebral response of acupuncture deqi: paradox underway. Evid Based Complement Altern Med 2013: pp. 894750
  30. Varrone, A, Asenbaum, S, Vander Borght, T, Booij, J, Nobili, F, N氓gren, K, Darcourt, J, Kapucu, 脰L, Tatsch, K, Bartenstein, P (2009) EANM procedure guidelines for PET brain imaging using [18F]FDG, version 2. Eur J Nucl Med Mol Imaging 36: pp. 2103-2110 CrossRef
  31. Schreckenberger, M, Spetzger, U, Sabri, O, Meyer, PT, Zeggel, T, Zimny, M, Gilsbach, J, Buell, U (2001) Localisation of motor areas in brain tumour patients: a comparison of preoperative [18F]FDG-PET and intraoperative cortical electrostimulation. Eur J Nucl Med 28: pp. 1394-1403 CrossRef
  32. Herholz, K, Pietrzyk, U, Karbe, H, W眉rker, M, Wienhard, K, Heiss, W-D (1994) Individual metabolic anatomy of repeating words demonstrated by MRI-guided positron emission tomography. Neurosci Lett 182: pp. 47-50 CrossRef
  33. Nuutila, P, Raitakari, M, Laine, H, Kirvel盲, O, Takala, T, Utriainen, T, M盲kimattila, S, Pitk盲nen, O-P, Ruotsalainen, U, Iida, H (1996) Role of blood flow in regulating insulin-stimulated glucose uptake in humans. Studies using bradykinin,[15O] water, and [18F]Fluoro-deoxy-glucose and positron emission tomography. J Clin Investig 97: pp. 1741 CrossRef
  34. Brown, CA, Jones, AK (2008) A role for midcingulate cortex in the interruptive effects of pain anticipation on attention. Clin Neurophysiol 119: pp. 2370-2379 CrossRef
  35. Langevin, HM, Wayne, PM, MacPherson, H, Schnyer, R, Milley, RM, Napadow, V, Lao, L, Park, J, Harris, RE, Cohen, M (2010) Paradoxes in acupuncture research: strategies for moving forward. Evid Based Complement Altern Med 2011: pp. 1-11 CrossRef
  36. Li, X, Liu, X, Song, W, Tang, Y, Zeng, F, Liang, F (2008) Effect of acupuncture at acupoints of the Shaoyang Meridian on cerebral glucose metabolism in the patient of chronic migraine. Zhongguo Zhen Jiu 28: pp. 854-859
  37. Iannetti, G, Zambreanu, L, Wise, R, Buchanan, T, Huggins, J, Smart, T, Vennart, W, Tracey, I (2005) Pharmacological modulation of pain-related brain activity during normal and central sensitization states in humans. Proc Natl Acad Sci U S A 102: pp. 18195-18200 CrossRef
  38. Pereira, MG, Oliveira, L, Erthal, FS, Joffily, M, Mocaiber, IF, Volchan, E, Pessoa, L (2010) Emotion affects action: midcingulate cortex as a pivotal node of interaction between negative emotion and motor signals. Cogn Affect Behav Neurosci 10: pp. 94-106 CrossRef
  39. Nagai, M, Kishi, K, Kato, S (2007) Insular cortex and neuropsychiatric disorders: a review of recent literature. Eur Psychiatry 22: pp. 387-394 CrossRef
  40. Afridi, SK, Giffin, NJ, Kaube, H, Friston, KJ, Ward, NS, Frackowiak, RS, Goadsby, PJ (2005) A positron emission tomographic study in spontaneous migraine. Arch Neurol 62: pp. 1270-1275 CrossRef
  
• 刊物主题：Biomedicine general; Medicine/Public Health, general;
• 出版者：BioMed Central
• ISSN：1479-5876

文摘

Background Acupuncture has analgesic effect to most pain conditions. Many neuroimaging studies were conducted to explore acupoint specificity in pain and other condition, but till now there is still discrepancy. Based on our previous finding, this study investigated the brain metabolism changes of acupuncture analgesia induced by sub-specific acupoint and non-acupoint stimulation. Methods 30 migraineurs were included and randomly assigned to 3 groups: Acupuncture Group (AG), Sham Acupuncture Group (SAG) and Migraine Group (MG). In AG, a combination sub-specific points of Shaoyang meridians, Luxi (TE19), San Yangluo (TE8), and Xi Yangguan(GB33) has been stimulated with electroacupuncture, while non-acupoints for SAG were used and MG received no treatment. Positron emission tomography with computed tomography (PET-CT) was used to identify differences in brain glucose metabolism between groups. Results In the AG, brain glucose metabolism increase compared with the MG was observed in the middle frontal gyrus, postcentral gyrus, the precuneus, parahippocampus, cerebellum and middle cingulate cortex (MCC), and decrease were observed in the left hemisphere of Middle Temporal Cortex (MTC).In the SAG, compared with MG, glucose metabolism increased in the poster cingulate cortex (PCC), insula, inferior temporal gyrus, MTC, superior temporal gyrus, postcentral gyrus, fusiform, inferior parietal lobe, superior parietal lobe, supramarginal gyrus, middle occipital lobe, angular and precuneus; while, decreased in cerebellum, parahippocampus. Conclusions Acupuncture stimulation at both sub-specific acupoint and non-acupoint yields ameliorating effect to migraine pain, but with evidently differed central mechanism as measured by PET-CT. The pattern of brain glucose metabolism change in acupoint is pertinent and targeted, while in non-acupoint that was disordered and randomized. These finding may provide new perspectives into the validation of acupoint specificity, optimizing acupuncture analgesia and revealing central mechanism of acupuncture analgesia by neuroimaging measurement. Trial registration This trial was registered in the Chinese Clinical Trial Registry, with registration no. ChiCTR-TRC-11001813.