Kinetics of angiogenic changes in a new mouse model for hepatocellular carcinoma
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- 作者：Femke Heindryckx (1)
Koen Mertens (2)
Nicolas Charette (3)
Bert Vandeghinste (4)
Christophe Casteleyn (5)
Christophe Van Steenkiste (1)
Dominique Slaets (6)
Louis Libbrecht (7)
Steven Staelens (4)
Peter Starkel (3)
Anja Geerts (1)
Isabelle Colle (1)
Hans Van Vlierberghe (1) - 刊名：Molecular Cancer
- 出版年：2010
- 出版时间：December 2010
- 年：2010
- 卷：9
- 期：1
- 全文大小：12163KB
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Koen Mertens (2)
Nicolas Charette (3)
Bert Vandeghinste (4)
Christophe Casteleyn (5)
Christophe Van Steenkiste (1)
Dominique Slaets (6)
Louis Libbrecht (7)
Steven Staelens (4)
Peter Starkel (3)
Anja Geerts (1)
Isabelle Colle (1)
Hans Van Vlierberghe (1)
1. Department of Gastroenterology and Hepatology, Ghent University Hospital, Ghent, Belgium
2. Department of Nuclear Medicine, Ghent University Hospital, Ghent, Belgium
3. Department of Gastroenterology, St. Luc University Hospital, Brussels, Belgium
4. Medical Signal and Image Processing, Ghent University-IBBT, Ghent, Belgium
5. Department of Morphology, Faculty of Veterinary science, Ghent University, Ghent, Belgium
6. Laboratory of Radiopharmacy, Faculty of Pharmaceutical Sciences, Ghent University, Ghent, Belgium
7. Department of Pathology, Ghent University Hospital, Ghent, Belgium - ISSN：1476-4598
文摘
Background The increasing incidence of hepatocellular carcinoma in Western countries has led to an expanding interest of scientific research in this field. Therefore, a vast need of experimental models that mimic the natural pathogenesis of hepatocellular carcinoma (HCC) in a short time period is present. The goal of our study was (1) to develop an efficient mouse model for HCC research, in which tumours develop in a natural background of fibrosis and (2) to assess the time-dependent angiogenic changes in the pathogenesis of HCC. Methods Weekly intraperitoneal injections with the hepatocarcinogenic compound N-nitrosodiethylamine was applied as induction method and samples were taken at several time points to assess the angiogenic changes during the progression of HCC. Results The N-nitrosodiethylamine-induced mouse model provides well vascularised orthotopic tumours after 25 weeks. It is a representative model for human HCC and can serve as an excellent platform for the development of new therapeutic targets.