Function of CD147 in Atherosclerosis and Atherothrombosis

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• 作者：Cuiping Wang (1) (2)
  Rong Jin (2)
  Xiaolei Zhu (2)
  Jinchuan Yan (1)
  Guohong Li (2)
  
  1. Department of Cardiology ; Affiliated Hospital of Jiangsu University ; Zhenjiang ; Jiangsu province ; People鈥檚 Republic of China ; 212001
  2. Department of Neurosurgery ; LSU Health Science Center ; Shreveport ; LA ; 71103 ; USA
  
• 关键词：CD147 ; Atherosclerosis ; Atherothrombosis
• 刊名：Journal of Cardiovascular Translational Research
• 出版年：2015
• 出版时间：February 2015
• 年：2015
• 卷：8
• 期：1
• 页码：59-66
• 全文大小：449 KB
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• 刊物主题：Cardiology; Human Genetics; Biomedical Engineering; Biomedicine general; Medicine/Public Health, general;
• 出版者：Springer US
• ISSN：1937-5395

文摘

CD147, a member of the immunoglobulin super family, is a well-known potent inducer of extracellular matrix metalloproteinases. Studies show that CD147 is upregulated in inflammatory diseases. Atherosclerosis is a chronic inflammatory disease of the artery wall. Further understanding of the functions of CD147 in atherosclerosis and atherothrombosis may provide a new strategy for preventing and treating cardiovascular disease. In this review, we discuss how CD147 contributes to atherosclerosis and atherothrombosis.