Metformin targeting autophagy overcomes progesterone resistance in endometrial carcinoma

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• 作者：Zhihong Zhuo ; Aiming Wang ; Huimin Yu
• 关键词：Metformin ; Endometrial carcinoma ; Autophagy ; Progesterone resistance
• 刊名：Archives of Gynecology and Obstetrics
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：294
• 期：5
• 页码：1055-1061
• 全文大小：628 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Gynecology
  Obstetrics and Perinatology
  Endocrinology
  Human Genetics
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-0711
• 卷排序：294

文摘

PurposeMetformin is the most prescribed anti-diabetic medication worldwide because of its proven efficacy and limited side effects. In this study, the significant anticancer effect of metformin was investigated in both endometrial carcinoma and progesterone-resistant endometrial carcinoma cells.