Telomere length and aging biomarkers in 70-year-olds: the Lothian Birth Cohort 1936

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• 作者：Sarah E. Harris^a ; ^b ; ^{Sarah.Harris@hgu.mrc.ac.uk} ; Carmen Martin-Ruiz^c ; Thomas von Zglinicki^c ; John M. Starr^d ; Ian J. Deary^b
• 关键词：Telomere ; Aging ; Biomarker ; Cognitive ; Social class ; Physical ; Inflammatory ; LBC1936
• 刊名：Neurobiology of Aging
• 出版年：2012
• 期刊代码：202_01974580
• 类别：med
• 出版时间：July, 2012
• 卷：33
• 期：7
• 页码：1486.e3-1486.e8
• 文件大小：416 K

摘要

Telomeres are nucleo-protein complexes at the end of eukaryotic chromosomes. They shorten each time a somatic cell replicates and this shortening is modulated by the effects of oxidative stress. Previous studies have associated telomere length with a number of age-related outcomes and it is hypothesized to be a quantitative indicator of aging. We tested this hypothesis in a cohort of 鈭?000 relatively healthy 70-year-old Scots (the Lothian Birth Cohort of 1936: LBC1936) on whom we have measures of cognition, physical health and associated traits, and social class. Telomeres were significantly longer in males than females (p < 0.0001). Longer telomeres were associated, in females only, with higher general cognitive ability scores (p = 0.022) and lower C-reactive protein levels (p = 0.014). Telomere length was not associated with any of the other measured cognitive, physical, or social traits. In conclusion we find little evidence that telomere length is a significant biomarker of normal aging in important cognitive and physical domains.