• 作者：L.S. G&#243 ; mez-Guerra ; A.U. Herná ; ndez-Torres ; A. Blanco-Guzmá ; n ; D.E. Solí ; s-Rodrí ; guez ; G.E. Ortiz-Lara ; J.R. Corté ; s-Gonzá ; lez ; ^{drjeffrcortes@gmail.com}
• 关键词：Í ; ndice de masa corporal ; Antí ; geno prostá ; tico especí ; fico ; Cá ; ncer de pró ; stata ; Sobrepeso ; Obesidad
• 刊名：Actas Urol贸gicas Espa帽olas
• 出版年：2012
• 期刊代码：pca37_02104806
• 类别：med
• 出版时间：May, 2012
• 卷：36
• 期：5
• 页码：302-305
• 文件大小：573 K

Objective

To evaluate the effect of body mass index (BMI) on PSA in northeast Mexican patients included in prostate cancer (Pca) early detection screening campaigns offered by our institution.

Material and methods

One hundred and ninety seven patients came voluntarily to our Pca early detection screening campaigns. Exclusion criteria: PSA &gt;10 ng/dl, patients on 5-伪 Reductase inhibitors or hormonal replacement. Overweight and obesity were considered when BMI was between 25-29.9 and 鈮?0 kg/m² respectively. Simple linear and multiple regression were used in the statistical analysis. Mean and standard deviation were utilized to evaluate spread and normal distribution. P values <0.05 were considered statistically significant.

Results

One hundred and fifty two patients were included in this study. Forty four percent (83) and 30.3%(46) presented with overweight and obesity, respectively. Mean BMI was 28.16 kg/m² (SD 1.77). A statistically significant negative effect of BMI on PSA was observed in the linear regression. This effect persisted when adjusted for age in the multiple regression model. A decrease of 0.085 ng/dl for every unit of BMI (p <0.001) was observed in the simple linear regression. This value was 0.07 in the multiple regression (p = 0.006)

Conclusions

A higher negative effect of BMI on PSA was found in comparison to published literature. A higher proportion of patients with BMI &gt;25 kg/m² than the national mean was observed. A multicentric national study is needed in order to challenge these results.