• 作者：J. Rubio-Briones^a ; ^{jrubio@fivo.org} ; A. Ferná ; ndez-Serra^b ; M. Ramí ; rez^a ; L. Rubio^b ; A. Collado^a ; J. Casanova^a ; A. G&#243 ; mez-Ferrer^a ; J.V. Ric&#243 ; s^a ; J.L. Monr&#243 ; s^a ; R. Dumont^a ; B. Ortiz^c ; I. Iborra^a ; Z. Garcí ; a-Casado^b ; E. Solsona^a ; J.A. L&#243 ; pez-Guerrero^b
• 关键词：PCA3 score ; Predicció ; n ; Cá ; ncer de pró ; stata ; PSA ; Biopsia de pró ; stata
• 刊名：Actas Urol贸gicas Espa帽olas
• 出版年：2011
• 期刊代码：pca37_02104806
• 类别：med
• 出版时间：November-December 2011
• 卷：35
• 期：10
• 页码：589-596
• 文件大小：275 K

lass="h4">Objectives

DD3^PCA3 (PCA3) gene expression is prostate cancer-specific. Routine use of this biomarker has resulted in a 35-67%reduction in the number of required biopsies. The aim of this study is to evaluate our outcomes in its routine use and to establish in which group of patients this is the most efficient, depending on the number of previous PCA3 biopsies.

lass="h4">Material and methods

A total of 474 consecutive patients who had previously undergone a biopsy (group A, n = 337) or not (group B, n = 134) for whom a PCA3 was requested were analyzed. We subdivided group A into A₁ (a previous biopsy, n = 182) and A₂ (<1 previous biopsy, n = 155). The recommendation of whether to perform a biopsy or not was made independently by each of the 11 clinicians and guided by prostatic specific antigen (PSA) levels and digital rectal examination.

lass="h4">Results

Median age was 65 years (range 38 to 84). PCA3 score had an informative ratio of 99.6%, with a median of 29 (range 1-3245). The percentage of biopsy sparing was 49%of the cases. ROC analysis demonstrated an AUC for PSA and PCA3 of 0.532 (P = .417) and 0.672 (P < .0001), respectively. Sensitivities of PSA鈮?4 and PCA3鈮?35 were 87%vs. 85%, with specificities of 12%vs. 33%, PPV 34%vs. 39%and NPV 63%vs. 81%, respectively. The PCA3 score showed direct correlation with the percentage of positive biopsies (P < .0001).

lass="h4">Conclusions

Routine use of PCA3, due to its high NPV, results in a significant reduction in the number of biopsies. PCA3 appears to be more efficient in biopsy-naive patients. Among patients already biopsied, the results are superior in those biopsied only once.