Quinolinyl- and phenantridinyl-acetamides as bradykinin B1 receptor antagonists

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• 作者：J&aacute ; nos É ; les ; ^{j.eles@richter.hu} ; Gyula Beke ; Istv&aacute ; n V&aacute ; gó ; É ; va Bozó ; Jó ; zsef Husz&aacute ; r ; &Aacute ; kos Tarcsay ; S&aacute ; ndor Kolok ; É ; va Schmidt ; Mó ; nika Vastag ; Katalin Hornok ; S&aacute ; ndor Farkas ; Gyö ; rgy Dom&aacute ; ny ; Gyö ; rgy M. Keser疟
• 关键词：Bradykinin ; B1 Antagonists ; Quinoline ; Phenantridine
• 刊名：Bioorganic and Medicinal Chemistry Letters
• 出版年：2012
• 期刊代码：10_0960894x
• 类别：ch
• 出版时间：1 May, 2012
• 卷：22
• 期：9
• 页码：3095-3099
• 文件大小：769 K

摘要

A new series of quinolinyl- and phenantridinyl-acetamides were synthesizer and evaluated against bradykinin B1 receptor. In vitro metabolic stability data were reported for the key compounds.The analgesic effect of compound 20 from the phenantridine series was proved in-vivo.