MWCNTs/Cu(OH)₂ nanoparticles/IL nanocomposite modified glassy carbon electrode as a voltammetric sensor for determination of the non-steroidal anti-inflammatory drug diclofenac

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• 作者：Majid Arvand ; ^{arvand@guilan.ac.ir} ; Tahereh M. Gholizadeh ; Mohammad Ali Zanjanchi
• 关键词：Nanocomposite ; Cu(OH)2 nanoparticles ; Ionic liquid ; Multiwalled carbon nanotubes ; Diclofenac ; Drug analysis
• 刊名：Materials Science and Engineering ; C
• 出版年：2012
• 期刊代码：63_09284931
• 类别：ms
• 出版时间：1 August, 2012
• 卷：32
• 期：6
• 页码：1682-1689
• 文件大小：1585 K

摘要

This paper describes the development and utilization of a new nanocomposite consisting of Cu(OH)₂ nanoparticles, hydrophobic ionic liquid 1-ethyl-3-methylimidazolium hexafluorophosphate (EMIMPF₆) and multiwalled carbon nanotubes for glassy carbon electrode modification. The nanocomposite was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM) along with energy-dispersive X-ray spectroscopy (EDX). The modified electrode was used for electrochemical characterization of diclofenac. Using differential pulse voltammetry, the prepared sensor showed good sensitivity and selectivity with low overpotential for the determination of diclofenac in the range from 0.18 to 119 渭M, with a detection limit of 0.04 渭M. Electrochemical studies suggested that the MWCNTs/Cu(OH)₂ nanoparticles/IL nanocomposite modified electrode provided a synergistic augmentation on the voltammetric behavior of electrochemical oxidation of diclofenac, which was indicated by the improvement of anodic peak current.