Stearoyl-CoA Desaturase 1 (SCD1) is a key factor mediating diabetes in MyD88-deficient mice
- 作者：Shota Yokoyama <sup>b060720@hiroshima-u.ac.jpsup> ; Toru Hosoi<sup> ; sup><sup>toruh@hiroshima-u.ac.jpsup> ; Koichiro Ozawa<sup> ; sup><sup>ozawak@hiroshima-u.ac.jpsup>
- 关键词：TLR4 ; toll-like receptor 4 ; MyD88 ; myeloid differentiation factor 88 ; SCD-1 ; stearoyl-CoA Desaturase 1 ; IRAK ; interleukin1 receptor-associated kinase ; TRAF6 ; TNF receptor-associated factor 6 ; G6Pase ; glucose-6-phosphatase ; GLUT2 ; glucose transporter 2
- 刊名：Gene
- 出版年：2012
- 期刊代码：73_03781119
- 类别：bio
- 出版时间：15 April, 2012
- 卷：497
- 期：2
- 页码：340-343
- 文件大小：259 K
摘要
Saturated fatty acids, acting as ligands for toll-like receptor 4 (TLR4), induce inflammation and mediate the development of insulin resistance. Myeloid differentiation factor 88 (MyD88) is an adaptor protein for TLR4. Previously, we found MyD88-deificient mice fed a high-fat diet (HFD) exhibited a severe diabetic phenotype. Stearoyl-CoA Desaturase 1 (SCD1) is the rate-limiting enzyme in the biosynthesis of monounsaturated fatty acids and known as a risk factor of diabetes. In the present study, we found SCD1 was dramatically increased in HFD-fed MyD88-deficient mice liver. This finding showed the novel linkage between MyD88 and SCD1 in the development of diabetes mellitus.