Transgenic over expression of nicotinic receptor alpha 5, alpha 3, and beta 4 subunit genes reduces ethanol intake in mice

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• 作者：Xavier Gallego^a ; ^b ; ¹ ; Jessica Ruiz-Medina^c ; Olga Valverde^c ; Susanna Molas^a ; ^b ; Noemí ; Robles^d ; Josefa Sabrià ; ^d ; John C. Crabbe^e ; Mara Dierssen^a ; ^b ; ^{mara.dierssen@crg.es}
• 关键词：Nicotine ; Ethanol ; Transgenic mice ; nAChR subunits ; Preference drinking ; Dependence
• 刊名：Alcohol
• 出版年：2012
• 期刊代码：1_07418329
• 类别：neu
• 出版时间：May, 2012
• 卷：46
• 期：3
• 页码：205-215
• 文件大小：684 K

摘要

Abuse of alcohol and smoking are extensively co-morbid. Some studies suggest partial commonality of action of alcohol and nicotine mediated through nicotinic acetylcholine receptors (nAChRs). We tested mice with transgenic over expression of the alpha 5, alpha 3, beta 4 receptor subunit genes, which lie in a cluster on human chromosome 15, that were previously shown to have increased nicotine self-administration, for several responses to ethanol. Transgenic and wild-type mice did not differ in sensitivity to several acute behavioral responses to ethanol. However, transgenic mice drank less ethanol than wild-type in a two-bottle (ethanol vs. water) preference test. These results suggest a complex role for this receptor subunit gene cluster in the modulation of ethanol's as well as nicotine's effects.