Risk of smoking and body mass index for incidence of diabetes mellitus in a rural Japanese population

详细信息	查看全文 | 推荐本文 |

• 作者：Akiko Morimoto^a ; ^b ; ^{aki62@belle.shiga-med.ac.jp} ; Yuko Ohno^a ; Yukako Tatsumi^a ; Yoshio Nishigaki^c ; Fumio Maejima^c ; Shoichi Mizuno^d ; Shaw Watanabe^e
• 关键词：Diabetes mellitus ; Smoking ; Body mass index ; Prospective study ; Individual and population risk
• 刊名：Preventive Medicine
• 出版年：2012
• 期刊代码：306_00917435
• 类别：med
• 出版时间：1 May, 2012
• 卷：54
• 期：5
• 页码：341-344
• 文件大小：141 K

摘要

Objective

To assess the risk of smoking, body mass index (BMI), and both for incidence of diabetes in a rural Japanese population.

Method

This study was a 10.1-year cohort study of 2070 men and 3802 women aged 40-69 years without diabetes at baseline who underwent a health check-up at one central hospital in Nagano Prefecture. Participants were classified according to a combination of smoking status and BMI. Participants were followed from 1990 to 2006. The incidence of diabetes was determined from fasting and random levels of plasma glucose, HbA_1c levels or being under medical treatment for diabetes.

Results

Diabetes developed in 595 of the participants during 59,111 person-years of follow-up. In men, the multivariable-adjusted hazard ratios for incidence of diabetes compared with non-smokers of normal weight were as follows: 3.36 (2.02-5.60) in current smokers with normal weight and 1.70 (0.87-3.34) and 3.93 (2.22-6.96) in obese non-smokers and obese current smokers, respectively. In men the population-attributable fraction of diabetes onset due to current smoking, obesity and both were 22.0%, 2.5%and 11.2%, respectively.

Conclusion

Regardless of BMI, smoking is an important risk factor for diabetes in male populations with a high prevalence of smoking.