Analgesic effect of magnetic stimulation on paclitaxel-induced peripheral neuropathic pain in mice
- 作者：Nozomi Ami ; Nozomi_Ami@terumo.co.jp ; Kazuo Okamoto ; Hidehiko Oshima
- 关键词：CIPN ; chemotherapy-induced peripheral neuropathy ; Ca伪2ð ; -1 ; voltage-gated calcium channel 伪2ð ; -1 subunit ; DRG ; dorsal root ganglion
- 刊名：Brain Research
- 出版年：2012
- 期刊代码：8_00068993
- 类别：neu
- 出版时间：21 June, 2012
- 卷：1461
- 期：Complete
- 页码：24-29
- 文件大小：386 K
摘要
Peripheral neuropathies are common side effects of chemotherapeutic drugs, including taxanes, platinum-based drugs, vinca alkaloids, and thalidomide. The most common symptoms are numbness, tingling and/or burning pain in a stocking-glove distribution. Severe peripheral neuropathies result in dose reductions, a change in chemotherapy regimen, or early cessation of chemotherapy. There are no proven interventions to prevent or treat chemotherapy-induced peripheral neuropathy. We designed and built a unique magnetic stimulator to clarify the effects of magnetic stimulation in the mouse paclitaxel-induced peripheral neuropathic pain model. Magnetic stimulation significantly reversed paclitaxel-induced mechanical hyperalgesia. The analgesic efficacy of magnetic stimulation was inhibited by naloxone, a 渭 opioid receptor antagonist. These findings indicate that the analgesic effect of magnetic stimulation is likely to be mediated by the endogenous opioid system. Furthermore, a combination of magnetic stimulation and pregabalin, a Ca2+ channel blocker, induced a potent combinational analgesic effect, suggesting that analgesic drug dose reduction might be possible. These findings indicate that there is a potential therapeutic utility for magnetic stimulation in pain relief.