Combined treatment with pegylated interferon (α-2b) and ribavirin in the acute phase of hepatitis C virus recurrence after liver transplantation

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• 作者：Lluí ; s Castells ; Ví ; ctor Vargas ; Helena Allende ; Itxarone Bilbao ; José ; Luis Lá ; zaro ; Carlos Margarit ; Rafael Esteban and Jaime Guardia
• 刊名：Journal of Hepatology
• 出版年：2005
• 期刊代码：162_01688278
• 类别：med
• 出版时间：2005
• 卷：43
• 期：1
• 页码：53-59
• 文件大小：136 K

摘要

Background/Aims

The efficacy and safety of treatment with pegylated interferon α-2b (Peg-Intron,™ 1.5 μg/kg) and ribavirin (400–800 mg) in the acute phase of recurrent HCV after LT is presented.

Methods

Twenty-four patients (17 men) transplanted for HCV-associated cirrhosis (genotype 1b) were treated for at least 6 months and compared with 24 consecutive transplant patients (16 men) without antiviral therapy (controls).

Results

At completion of treatment, 14/24 treated patients (58%) achieved HCV-RNA negativity, compared to none of controls (P<0.0001). Sustained virological response (SVR) occurred in 8/23 treated patients (34.7%) who reached week 24 after treatment and none of controls (P<0.005). At 12 weeks after treatment, 15/24 patients (62.5%) had an early virological response (EVR) (seven tested HCV-RNA negative). SVR was associated with absence of corticosteroid bolus administration (P=0.01), presence of EVR (P=0.002) and absence of cytomegalovirus infection (P=0.001). Haematological adverse effects included anaemia, 17/24 cases (71%) and leukopenia, 23/24 cases (96%). One patient presented mild acute rejection that resolved by adjusting immunosuppressive dose.

Conclusions

Treatment with pegylated interferon α-2b plus ribavirin in the acute phase of HCV reinfection yielded an EVR of 62.5%and a SVR of 34.7%. The combination was safe, with a low rate of therapy withdrawal.