The T29C polymorphism of the transforming growth factor-尾1 (TGF-尾1) gene is associated with genetic susceptibility to acute coronary syndrome in Mexican patients

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• 作者：José ; Manuel Fragoso^a ; ^{mfragoso1275@yahoo.com.mx} ; Marco Antonio Martí ; nez-Rí ; os^b ; ^{mtzrios@gmail.com} ; Edith Alvarez-Leó ; n^a ; ^{edalvaleo@yahoo.com} ; Maite Vallejo^c ; ^{maite_vallejo@yahoo.com.mx} ; Marco Antonio Peñ ; a-Duque^b ; ^{penmar@cardiologia.org.mx} ; Rosalinda Posadas-Sá ; nchez^d ; ^{rossy_posadas_s@yahoo.it} ; Carlos Posadas-Romero^d ; ^{cposadasr@yahoo.com} ; Janette Furuzawa-Carballeda^e ; ^{jfuruzawa@gmail.com} ; Guadalupe Lima^e ; ^{lupitalimag@yahoo.com} ; Luis Llorente^e ; ^{luisllorentepeters57@gmail.com} ; Gilberto Vargas-Alarcó ; n^a ; ^{gvargas63@yahoo.com}
• 关键词：Acute coronary syndrome ; Cytokine ; Genetic susceptibility ; Polymorphisms ; TGF-尾1
• 刊名：Cytokine
• 出版年：2012
• 期刊代码：97_10434666
• 类别：imm
• 出版时间：June, 2012
• 卷：58
• 期：3
• 页码：380-383
• 文件大小：183 K

摘要

Inflammation plays an essential role in the development and progression of atherosclerotic lesions, and plaque disruption. The m>TGF-尾1m> plays an important role in the anti-inflammatory process. The aim of the present study was to evaluate the role of m>TGF-尾1m> gene polymorphisms as susceptibility markers for acute coronary syndrome (ACS). Two polymorphisms (m>TGF-尾 -509Tm> > m>Cm> and m>TGF-尾 T29Cm>) of the m>TGF-尾m> gene were analyzed by 5鈥?exonuclease TaqMan genotyping assays in a group of 426 patients with coronary acute syndrome and 551 healthy unrelated controls. A significant difference was observed in the distribution of m>TGF-尾 T29Cm> polymorphism between ACS patients and healthy controls (m>Pm> < 10^鈭?). According to the co-dominant model, individuals with the m>TGF-尾 29 TTm> genotype have a 2.5-fold increased risk of developing ACS (m>Pm> < 10^鈭?). Multiple logistic analysis showed that the largest risk factor for developing ACS was given by smoking habit, diabetes, hypertension, dyslipidemia, and the m>TGF-尾1 29 TTm> genotype. The analysis of linkage disequilibrium showed one haplotype (m>TTm>) with increased frequency and one haplotype (m>CCm>) with decreased frequency in ACS patients when compared to healthy controls. The results suggest that m>TGF-尾1 T29Cm> gene polymorphism could be involved in the risk of developing ACS in Mexican individuals.