NMR study on Pt(II) interaction with Amadori compounds
- 作者：Erika Ferrari ; Romano Gr ; i ; S ; ra Lazzari ; Monica Saladini
- 关键词：Amadori compounds ; Cisplatin analogs ; <sup>195sup>Pt NMR
- 刊名：Inorganica Chimica Acta
- 出版年：2007
- 期刊代码：40_00201693
- 类别：ch
- 出版时间：10 June 2007
- 卷：360
- 期：9
- 页码：3119-3122
- 文件大小：233 K
摘要
Here we report the first evidence of Pt(II) interaction with Amadori compound [N-(1-deoxy-d-Fructos-1-yl)glycine (Fru-Hgly)]. The <sup>1sup>H and <sup>195sup>Pt NMR results show that complexation of Pt(II) by Fru-Hgly is strongly dependent on pH and reaction molar ratio. In 1/1 Pt/Fru-Hgly molar ratio, at acidic pH, the first coordination site is the carboxylic oxygen, while at physiological pH the anchoring group is the aminic one, in both cases the system slowly evolves towards an N,O chelating mode. In 1/2 Pt/Fru-Hgly molar ratio the only coordination site is nitrogen atom while the carboxylic oxygen is not involved in metal coordination.